Gender differences of morphological and hemodynamic characteristics of abdominal aortic aneurysm
Abstract Background Gender difference in cardiovascular diseases (CVDs) is an important topic in the field of cardiovascular medicine. In this study, we focused on the mortality difference of abdominal aortic aneurysms (AAA), which is higher for female than that of male. The aim of this study was to...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-07-01
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| Series: | Biology of Sex Differences |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13293-020-00318-3 |
| _version_ | 1828765803747475456 |
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| author | Zujie Gao Jiang Xiong Zengsheng Chen Xiaoyan Deng Zaipin Xu Anqiang Sun Yubo Fan |
| author_facet | Zujie Gao Jiang Xiong Zengsheng Chen Xiaoyan Deng Zaipin Xu Anqiang Sun Yubo Fan |
| author_sort | Zujie Gao |
| collection | DOAJ |
| description | Abstract Background Gender difference in cardiovascular diseases (CVDs) is an important topic in the field of cardiovascular medicine. In this study, we focused on the mortality difference of abdominal aortic aneurysms (AAA), which is higher for female than that of male. The aim of this study was to verify whether morphological and hemodynamic factors play their roles in this phenomenon. Methods Patient-specific AAA models of 11 females and 23 males with similar age and body mass index (BMI) have been reconstructed based on clinical computed tomography (CT) data. Firstly, the morphological parameters (diameters, curvature, intraluminal thrombus volume, etc.) of AAA models and lumbar vertebrae models were collected and analyzed. Then, based on statistical results of morphological parameters, uniformed male and female AAA models were reconstructed, and hemodynamic simulations were conducted respectively. In post-processing, the hemodynamic performances induced by gender-different morphological geometries were analyzed and compared. Results The comparison of morphological parameters revealed that the average curvature of lumbar vertebrae and AAA centerline of female AAA models were obviously higher than that of the male. The amount of intraluminal thrombus in female AAA models was relatively lower than that of the male. According to the hemodynamic simulation, the uniform female AAA model has higher peak pressure, lower oscillatory shear stress index (OSI), and lower relative residence time (RRT) than that of the male model, all of which put female AAA to a relatively higher risk hemodynamic situation. Conclusions The morphological and hemodynamic features of AAA have very obvious gender differences that would induce higher risk of rupture for female AAA biomechanically. These findings would help to explore the mechanism of gender differences in AAA and draw attention to gender-specific consideration for AAA treatment. More morphological and hemodynamic indictors are suggested to be involved in the future guidelines. |
| first_indexed | 2024-12-11T06:54:32Z |
| format | Article |
| id | doaj.art-7f8cd10671324a88af98168bfd98cccb |
| institution | Directory Open Access Journal |
| issn | 2042-6410 |
| language | English |
| last_indexed | 2024-12-11T06:54:32Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology of Sex Differences |
| spelling | doaj.art-7f8cd10671324a88af98168bfd98cccb2022-12-22T01:16:48ZengBMCBiology of Sex Differences2042-64102020-07-0111111010.1186/s13293-020-00318-3Gender differences of morphological and hemodynamic characteristics of abdominal aortic aneurysmZujie Gao0Jiang Xiong1Zengsheng Chen2Xiaoyan Deng3Zaipin Xu4Anqiang Sun5Yubo Fan6School of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beihang UniversityDepartment of Vascular and Endovascular Surgery, The Chinese PLA General HospitalSchool of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beihang UniversitySchool of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beihang UniversityCollege of Animal Science, Guizhou UniversitySchool of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beihang UniversitySchool of Biological Science and Medical Engineering, Beijing Advanced Innovation Center for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beihang UniversityAbstract Background Gender difference in cardiovascular diseases (CVDs) is an important topic in the field of cardiovascular medicine. In this study, we focused on the mortality difference of abdominal aortic aneurysms (AAA), which is higher for female than that of male. The aim of this study was to verify whether morphological and hemodynamic factors play their roles in this phenomenon. Methods Patient-specific AAA models of 11 females and 23 males with similar age and body mass index (BMI) have been reconstructed based on clinical computed tomography (CT) data. Firstly, the morphological parameters (diameters, curvature, intraluminal thrombus volume, etc.) of AAA models and lumbar vertebrae models were collected and analyzed. Then, based on statistical results of morphological parameters, uniformed male and female AAA models were reconstructed, and hemodynamic simulations were conducted respectively. In post-processing, the hemodynamic performances induced by gender-different morphological geometries were analyzed and compared. Results The comparison of morphological parameters revealed that the average curvature of lumbar vertebrae and AAA centerline of female AAA models were obviously higher than that of the male. The amount of intraluminal thrombus in female AAA models was relatively lower than that of the male. According to the hemodynamic simulation, the uniform female AAA model has higher peak pressure, lower oscillatory shear stress index (OSI), and lower relative residence time (RRT) than that of the male model, all of which put female AAA to a relatively higher risk hemodynamic situation. Conclusions The morphological and hemodynamic features of AAA have very obvious gender differences that would induce higher risk of rupture for female AAA biomechanically. These findings would help to explore the mechanism of gender differences in AAA and draw attention to gender-specific consideration for AAA treatment. More morphological and hemodynamic indictors are suggested to be involved in the future guidelines.http://link.springer.com/article/10.1186/s13293-020-00318-3Gender differenceAbdominal aortic aneurysmHemodynamicsMorphological |
| spellingShingle | Zujie Gao Jiang Xiong Zengsheng Chen Xiaoyan Deng Zaipin Xu Anqiang Sun Yubo Fan Gender differences of morphological and hemodynamic characteristics of abdominal aortic aneurysm Biology of Sex Differences Gender difference Abdominal aortic aneurysm Hemodynamics Morphological |
| title | Gender differences of morphological and hemodynamic characteristics of abdominal aortic aneurysm |
| title_full | Gender differences of morphological and hemodynamic characteristics of abdominal aortic aneurysm |
| title_fullStr | Gender differences of morphological and hemodynamic characteristics of abdominal aortic aneurysm |
| title_full_unstemmed | Gender differences of morphological and hemodynamic characteristics of abdominal aortic aneurysm |
| title_short | Gender differences of morphological and hemodynamic characteristics of abdominal aortic aneurysm |
| title_sort | gender differences of morphological and hemodynamic characteristics of abdominal aortic aneurysm |
| topic | Gender difference Abdominal aortic aneurysm Hemodynamics Morphological |
| url | http://link.springer.com/article/10.1186/s13293-020-00318-3 |
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