Association of the s1799724 and rs1800629 Polymorphisms of the TNF-α Gene with Susceptibility to Cervical Cancer: a Systematic Review and Meta-Analysis based on 24 Case-Control Studies
Objective: Some studies have recently focused on the association between TNF-α polymorphisms and cervical cancer; however, results have been inconsistent. In order to drive a more precise estimation, the present systematic review and meta-analysis is performed to investigate the relationship of the...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
West Asia Organization for Cancer Prevention
2017-04-01
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| Series: | Asian Pacific Journal of Cancer Care |
| Subjects: | |
| Online Access: | http://www.waocp.com/journal/index.php/apjcc/article/view/65 |
| _version_ | 1827373025031356416 |
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| author | Sedigheh Hamadani Mahdieh Kamali Sedigheh Hantoushzadeh Razieh Sadat Tabatabaee Hossein Neamatzadeh Elnaz Foroughi Fatemeh Haghighi Masoud Zare-Shehneh Elham Alsadat Hejazian-Yazdi |
| author_facet | Sedigheh Hamadani Mahdieh Kamali Sedigheh Hantoushzadeh Razieh Sadat Tabatabaee Hossein Neamatzadeh Elnaz Foroughi Fatemeh Haghighi Masoud Zare-Shehneh Elham Alsadat Hejazian-Yazdi |
| author_sort | Sedigheh Hamadani |
| collection | DOAJ |
| description | Objective: Some studies have recently focused on the association between TNF-α polymorphisms and cervical cancer; however, results have been inconsistent. In order to drive a more precise estimation, the present systematic review and meta-analysis is performed to investigate the relationship of the TNF-α rs1800629 and s1799724 polymorphisms with cervical cancer risk.
Methods: An electronic search was conducted on PubMed, Web of Science, and Google scholar databases, for papers that describe the association between TNF-α polymorphisms and cervical cancer risk.
Results: A number of 24 case-control studies in 22 publications were identified according to the inclusion criteria. The results showed that rs1800629 polymorphism was significantly associated with the increased cervical cancer risk under four genetic models (A vs. G: OR = 1.277, 95% CI: 1.104-1.477, p = 0.001; AA vs. GG: OR = 1.333, 95% CI: 1.062-1.674, p = 0.013; AG vs. GG: OR = 1.307, 95% CI: 1.064-1.605, p = 0.011; and AA+AG vs. GG: OR = 1.324, 95% CI: 1.104-1.587, p = 0.002). In stratified analysis, there was a significant association between rs1800629 polymorphism and cervical cancer risk in the subgroup of Caucasians and African, but not in Asians. However, no statistically significant association was observed between the s1799724 and cervical cancer risk under all genetic models. Furthermore, stratification by ethnicity indicated no association between the s1799724 and cervical cancer risk.
Conclusion: the present meta-analysis suggests that the rs1800629 polymorphism of the TNF-α gene was significantly associated with cervical cancer risk, but not s1799724. |
| first_indexed | 2024-03-08T11:09:26Z |
| format | Article |
| id | doaj.art-7f8cdd1d237640409012633d6ea18813 |
| institution | Directory Open Access Journal |
| issn | 2588-3682 |
| language | English |
| last_indexed | 2024-03-08T11:09:26Z |
| publishDate | 2017-04-01 |
| publisher | West Asia Organization for Cancer Prevention |
| record_format | Article |
| series | Asian Pacific Journal of Cancer Care |
| spelling | doaj.art-7f8cdd1d237640409012633d6ea188132024-01-26T13:47:53ZengWest Asia Organization for Cancer PreventionAsian Pacific Journal of Cancer Care2588-36822017-04-0122292910.31557/apjcc.2017.2.2.2965Association of the s1799724 and rs1800629 Polymorphisms of the TNF-α Gene with Susceptibility to Cervical Cancer: a Systematic Review and Meta-Analysis based on 24 Case-Control StudiesSedigheh Hamadani0Mahdieh KamaliSedigheh Hantoushzadeh1Razieh Sadat Tabatabaee2Hossein Neamatzadeh3Elnaz Foroughi4Fatemeh Haghighi5Masoud Zare-Shehneh6Elham Alsadat Hejazian-Yazdi7Department of Perinatology, School of Medicine, Tehran University Medical of Sciences, Maternal-Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Perinatology, School of Medicine, Tehran University Medical of Sciences, Maternal-Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Department of Pediatric Dentistry, Arak university of Medical Sciences, Arak, Iran.Department of Gynecology and Obstetrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Department of Physical Education, Yazd Branch, Islamic Azad University, Yazd, IranDepartment of Physical Education, Yazd Branch, Islamic Azad University, Yazd, IranObjective: Some studies have recently focused on the association between TNF-α polymorphisms and cervical cancer; however, results have been inconsistent. In order to drive a more precise estimation, the present systematic review and meta-analysis is performed to investigate the relationship of the TNF-α rs1800629 and s1799724 polymorphisms with cervical cancer risk. Methods: An electronic search was conducted on PubMed, Web of Science, and Google scholar databases, for papers that describe the association between TNF-α polymorphisms and cervical cancer risk. Results: A number of 24 case-control studies in 22 publications were identified according to the inclusion criteria. The results showed that rs1800629 polymorphism was significantly associated with the increased cervical cancer risk under four genetic models (A vs. G: OR = 1.277, 95% CI: 1.104-1.477, p = 0.001; AA vs. GG: OR = 1.333, 95% CI: 1.062-1.674, p = 0.013; AG vs. GG: OR = 1.307, 95% CI: 1.064-1.605, p = 0.011; and AA+AG vs. GG: OR = 1.324, 95% CI: 1.104-1.587, p = 0.002). In stratified analysis, there was a significant association between rs1800629 polymorphism and cervical cancer risk in the subgroup of Caucasians and African, but not in Asians. However, no statistically significant association was observed between the s1799724 and cervical cancer risk under all genetic models. Furthermore, stratification by ethnicity indicated no association between the s1799724 and cervical cancer risk. Conclusion: the present meta-analysis suggests that the rs1800629 polymorphism of the TNF-α gene was significantly associated with cervical cancer risk, but not s1799724.http://www.waocp.com/journal/index.php/apjcc/article/view/65tnf-α gene, cervical cancer, polymorphism, meta-analysis. |
| spellingShingle | Sedigheh Hamadani Mahdieh Kamali Sedigheh Hantoushzadeh Razieh Sadat Tabatabaee Hossein Neamatzadeh Elnaz Foroughi Fatemeh Haghighi Masoud Zare-Shehneh Elham Alsadat Hejazian-Yazdi Association of the s1799724 and rs1800629 Polymorphisms of the TNF-α Gene with Susceptibility to Cervical Cancer: a Systematic Review and Meta-Analysis based on 24 Case-Control Studies Asian Pacific Journal of Cancer Care tnf-α gene, cervical cancer, polymorphism, meta-analysis. |
| title | Association of the s1799724 and rs1800629 Polymorphisms of the TNF-α Gene with Susceptibility to Cervical Cancer: a Systematic Review and Meta-Analysis based on 24 Case-Control Studies |
| title_full | Association of the s1799724 and rs1800629 Polymorphisms of the TNF-α Gene with Susceptibility to Cervical Cancer: a Systematic Review and Meta-Analysis based on 24 Case-Control Studies |
| title_fullStr | Association of the s1799724 and rs1800629 Polymorphisms of the TNF-α Gene with Susceptibility to Cervical Cancer: a Systematic Review and Meta-Analysis based on 24 Case-Control Studies |
| title_full_unstemmed | Association of the s1799724 and rs1800629 Polymorphisms of the TNF-α Gene with Susceptibility to Cervical Cancer: a Systematic Review and Meta-Analysis based on 24 Case-Control Studies |
| title_short | Association of the s1799724 and rs1800629 Polymorphisms of the TNF-α Gene with Susceptibility to Cervical Cancer: a Systematic Review and Meta-Analysis based on 24 Case-Control Studies |
| title_sort | association of the s1799724 and rs1800629 polymorphisms of the tnf α gene with susceptibility to cervical cancer a systematic review and meta analysis based on 24 case control studies |
| topic | tnf-α gene, cervical cancer, polymorphism, meta-analysis. |
| url | http://www.waocp.com/journal/index.php/apjcc/article/view/65 |
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