Short-term clinical outcome of stroke patients with or without prior statin treatment
Objective(s): This study evaluated the impact of statin on the severity and outcome of stroke among patients who had taken it prior to the stroke onset and compared to patients who had not received it before the stroke. Methods: We included 261 consecutive patients with acute ischemic stroke who ad...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2021-03-01
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| Series: | Trends in Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://tips.sums.ac.ir/article_47391_e3bcec5b578e9a4cf6294a5bdba1aacf.pdf |
| _version_ | 1818730900100218880 |
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| author | Omid Mirzaee Abdolhamid Shariat Faezeh Sehatpour Mojtaba Neydavoodi Fatemeh Roozbeh Seyedeh Shaghayegh Zafarmand Maryam Owjfard Shekoofeh Rahimi Anahid Safari Afshin Borhani-Haghighi |
| author_facet | Omid Mirzaee Abdolhamid Shariat Faezeh Sehatpour Mojtaba Neydavoodi Fatemeh Roozbeh Seyedeh Shaghayegh Zafarmand Maryam Owjfard Shekoofeh Rahimi Anahid Safari Afshin Borhani-Haghighi |
| author_sort | Omid Mirzaee |
| collection | DOAJ |
| description | Objective(s): This study evaluated the impact of statin on the severity and outcome of stroke among patients who had taken it prior to the stroke onset and compared to patients who had not received it before the stroke. Methods: We included 261 consecutive patients with acute ischemic stroke who admitted in Namazee hospital affiliated to Shiraz University of Medical Sciences from 2018-2019. We recorded demographic data, vascular risk factors, history of previous statin treatment, and National Institutes of Health Stroke Scale (NIHSS) score at time of hospital admission and modified Rankin Scale (MRS) 3 months after stroke onset. The dependent variables were initial severity of stroke as measured by National Institute of Health Scoring System (NIHSS) and good outcome defined as modified Rankin Scale (MRS) 0 to 1. Results: Among 261 patients with acute ischemic stroke, 76 were using statins (52.6% of users were women). Among all the subjects, 175 (67.6%) had history of hypertension, 78 (30.1%) had history of diabetes mellitus, 87(33.5%) had history of hyperlipidemia, 63 (24.3%) were smokers. Admission NIHSS and MRS were not statistically different in statin users and non-statin users (P= 0.12 and P= 0.08, respectively). Adjusted Odds Ratios for poor functional outcome and 90-day mortality according to previous statin use were 0.87 (95% CI 0.37-2.05), P= 0.54) and 0.75(95% CI 0.31-1.81, P= 0.52) which were not statistically significant. Conclusion: This study showed that pre-stroke statin therapy did not affect the initial clinical severity, short-term functional outcome and 90-day mortality after ischemic stroke. |
| first_indexed | 2024-12-17T23:09:07Z |
| format | Article |
| id | doaj.art-7f8d7be54b6045ec8ac02cfa7754d792 |
| institution | Directory Open Access Journal |
| issn | 2423-5652 |
| language | English |
| last_indexed | 2024-12-17T23:09:07Z |
| publishDate | 2021-03-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Trends in Pharmaceutical Sciences |
| spelling | doaj.art-7f8d7be54b6045ec8ac02cfa7754d7922022-12-21T21:29:10ZengShiraz University of Medical SciencesTrends in Pharmaceutical Sciences2423-56522021-03-0171253210.30476/tips.2021.90388.108447391Short-term clinical outcome of stroke patients with or without prior statin treatmentOmid Mirzaee0Abdolhamid Shariat1Faezeh Sehatpour2Mojtaba Neydavoodi3Fatemeh Roozbeh4Seyedeh Shaghayegh Zafarmand5Maryam Owjfard6Shekoofeh Rahimi7Anahid Safari8Afshin Borhani-Haghighi9Students Research Committee, Shiraz University of Medical Sciences, Shiraz, IranClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, IranStudents Research Committee, Shiraz University of Medical Sciences, Shiraz, IranClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, IranStudents Research Committee, Shiraz University of Medical Sciences, Shiraz, IranClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, IranClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, IranStudents Research Committee, Shiraz University of Medical Sciences, Shiraz, IranStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, IranClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, IranObjective(s): This study evaluated the impact of statin on the severity and outcome of stroke among patients who had taken it prior to the stroke onset and compared to patients who had not received it before the stroke. Methods: We included 261 consecutive patients with acute ischemic stroke who admitted in Namazee hospital affiliated to Shiraz University of Medical Sciences from 2018-2019. We recorded demographic data, vascular risk factors, history of previous statin treatment, and National Institutes of Health Stroke Scale (NIHSS) score at time of hospital admission and modified Rankin Scale (MRS) 3 months after stroke onset. The dependent variables were initial severity of stroke as measured by National Institute of Health Scoring System (NIHSS) and good outcome defined as modified Rankin Scale (MRS) 0 to 1. Results: Among 261 patients with acute ischemic stroke, 76 were using statins (52.6% of users were women). Among all the subjects, 175 (67.6%) had history of hypertension, 78 (30.1%) had history of diabetes mellitus, 87(33.5%) had history of hyperlipidemia, 63 (24.3%) were smokers. Admission NIHSS and MRS were not statistically different in statin users and non-statin users (P= 0.12 and P= 0.08, respectively). Adjusted Odds Ratios for poor functional outcome and 90-day mortality according to previous statin use were 0.87 (95% CI 0.37-2.05), P= 0.54) and 0.75(95% CI 0.31-1.81, P= 0.52) which were not statistically significant. Conclusion: This study showed that pre-stroke statin therapy did not affect the initial clinical severity, short-term functional outcome and 90-day mortality after ischemic stroke.https://tips.sums.ac.ir/article_47391_e3bcec5b578e9a4cf6294a5bdba1aacf.pdfstrokeischemic strokestatin |
| spellingShingle | Omid Mirzaee Abdolhamid Shariat Faezeh Sehatpour Mojtaba Neydavoodi Fatemeh Roozbeh Seyedeh Shaghayegh Zafarmand Maryam Owjfard Shekoofeh Rahimi Anahid Safari Afshin Borhani-Haghighi Short-term clinical outcome of stroke patients with or without prior statin treatment Trends in Pharmaceutical Sciences stroke ischemic stroke statin |
| title | Short-term clinical outcome of stroke patients with or without prior statin treatment |
| title_full | Short-term clinical outcome of stroke patients with or without prior statin treatment |
| title_fullStr | Short-term clinical outcome of stroke patients with or without prior statin treatment |
| title_full_unstemmed | Short-term clinical outcome of stroke patients with or without prior statin treatment |
| title_short | Short-term clinical outcome of stroke patients with or without prior statin treatment |
| title_sort | short term clinical outcome of stroke patients with or without prior statin treatment |
| topic | stroke ischemic stroke statin |
| url | https://tips.sums.ac.ir/article_47391_e3bcec5b578e9a4cf6294a5bdba1aacf.pdf |
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