Molecular Mechanism of Natural Food Antioxidants to Regulate ROS in Treating Cancer: A Review
Cancer is the second-highest mortality rate disease worldwide, and it has been estimated that cancer will increase by up to 20 million cases yearly by 2030. There are various options of treatment for cancer, including surgery, radiotherapy, and chemotherapy. All of these options have damaging advers...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/13/2/207 |
| _version_ | 1797299028508016640 |
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| author | Muchtaridi Muchtaridi Farhah Az-Zahra Hendris Wongso Luthfi Utami Setyawati Dhania Novitasari Emmy Hainida Khairul Ikram |
| author_facet | Muchtaridi Muchtaridi Farhah Az-Zahra Hendris Wongso Luthfi Utami Setyawati Dhania Novitasari Emmy Hainida Khairul Ikram |
| author_sort | Muchtaridi Muchtaridi |
| collection | DOAJ |
| description | Cancer is the second-highest mortality rate disease worldwide, and it has been estimated that cancer will increase by up to 20 million cases yearly by 2030. There are various options of treatment for cancer, including surgery, radiotherapy, and chemotherapy. All of these options have damaging adverse effects that can reduce the patient’s quality of life. Cancer itself arises from a series of mutations in normal cells that generate the ability to divide uncontrollably. This cell mutation can happen as a result of DNA damage induced by the high concentration of ROS in normal cells. High levels of reactive oxygen species (ROS) can cause oxidative stress, which can initiate cancer cell proliferation. On the other hand, the cytotoxic effect from elevated ROS levels can be utilized as anticancer therapy. Some bioactive compounds from natural foods such as fruit, vegetables, herbs, honey, and many more have been identified as a promising source of natural antioxidants that can prevent oxidative stress by regulating the level of ROS in the body. In this review, we have highlighted and discussed the benefits of various natural antioxidant compounds from natural foods that can regulate reactive oxygen species through various pathways. |
| first_indexed | 2024-03-07T22:44:40Z |
| format | Article |
| id | doaj.art-7f8df5304dfa49318f1c384862eb096e |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-07T22:44:40Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-7f8df5304dfa49318f1c384862eb096e2024-02-23T15:05:30ZengMDPI AGAntioxidants2076-39212024-02-0113220710.3390/antiox13020207Molecular Mechanism of Natural Food Antioxidants to Regulate ROS in Treating Cancer: A ReviewMuchtaridi Muchtaridi0Farhah Az-Zahra1Hendris Wongso2Luthfi Utami Setyawati3Dhania Novitasari4Emmy Hainida Khairul Ikram5Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartment of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaResearch Collaboration Centre for Radiopharmaceuticals Theranostic, National Research and Innovation Agency (BRIN), Jln. Raya Bandung Sumedang Km. 21, Jatinangor 45363, IndonesiaDepartment of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaDepartment of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang 45363, IndonesiaIntegrated Nutrition Science and Therapy Research Group (INSPIRE), Faculty of Health Sciences, Universiti Teknologi MARA Cawangan Selangor, Kampus Puncak Alam, Bandar Puncak Alam 42300, MalaysiaCancer is the second-highest mortality rate disease worldwide, and it has been estimated that cancer will increase by up to 20 million cases yearly by 2030. There are various options of treatment for cancer, including surgery, radiotherapy, and chemotherapy. All of these options have damaging adverse effects that can reduce the patient’s quality of life. Cancer itself arises from a series of mutations in normal cells that generate the ability to divide uncontrollably. This cell mutation can happen as a result of DNA damage induced by the high concentration of ROS in normal cells. High levels of reactive oxygen species (ROS) can cause oxidative stress, which can initiate cancer cell proliferation. On the other hand, the cytotoxic effect from elevated ROS levels can be utilized as anticancer therapy. Some bioactive compounds from natural foods such as fruit, vegetables, herbs, honey, and many more have been identified as a promising source of natural antioxidants that can prevent oxidative stress by regulating the level of ROS in the body. In this review, we have highlighted and discussed the benefits of various natural antioxidant compounds from natural foods that can regulate reactive oxygen species through various pathways.https://www.mdpi.com/2076-3921/13/2/207cancermolecular mechanismnatural food antioxidantsreactive oxygen species (ROS)oxidative stress |
| spellingShingle | Muchtaridi Muchtaridi Farhah Az-Zahra Hendris Wongso Luthfi Utami Setyawati Dhania Novitasari Emmy Hainida Khairul Ikram Molecular Mechanism of Natural Food Antioxidants to Regulate ROS in Treating Cancer: A Review Antioxidants cancer molecular mechanism natural food antioxidants reactive oxygen species (ROS) oxidative stress |
| title | Molecular Mechanism of Natural Food Antioxidants to Regulate ROS in Treating Cancer: A Review |
| title_full | Molecular Mechanism of Natural Food Antioxidants to Regulate ROS in Treating Cancer: A Review |
| title_fullStr | Molecular Mechanism of Natural Food Antioxidants to Regulate ROS in Treating Cancer: A Review |
| title_full_unstemmed | Molecular Mechanism of Natural Food Antioxidants to Regulate ROS in Treating Cancer: A Review |
| title_short | Molecular Mechanism of Natural Food Antioxidants to Regulate ROS in Treating Cancer: A Review |
| title_sort | molecular mechanism of natural food antioxidants to regulate ros in treating cancer a review |
| topic | cancer molecular mechanism natural food antioxidants reactive oxygen species (ROS) oxidative stress |
| url | https://www.mdpi.com/2076-3921/13/2/207 |
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