Prescription Practices of Antifungal Agents at Gynaecology and Oncology Departments of a Tertiary Hospital in Mwanza, Tanzania: A Retrospective Study
Introduction: Irrational antifungals prescription results in inappropriate use of antifungals, leading to emergence of antifungal resistance. Aim: To determine the prescription patterns of antifungal agents in Gynaecology and Oncology Departments of the tertiary hospital in Tanzania. Materials...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2022-08-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/16786/55087_CE9AD)_F[SK]_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdf |
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| author | Kayo Hamasaki Zaomba Hussein Bernard Okamo Stanley Mwita Deogratius Katabaro Stephen E Mshana Martha F Mushi |
| author_facet | Kayo Hamasaki Zaomba Hussein Bernard Okamo Stanley Mwita Deogratius Katabaro Stephen E Mshana Martha F Mushi |
| author_sort | Kayo Hamasaki |
| collection | DOAJ |
| description | Introduction: Irrational antifungals prescription results in inappropriate use of antifungals, leading to emergence of antifungal resistance.
Aim: To determine the prescription patterns of antifungal agents in
Gynaecology and Oncology Departments of the tertiary hospital in
Tanzania.
Materials and Methods: This was a retrospective hospital-based
study involving files of patients who attended Gynaecology and
Oncology Department of Bugando Medical Centre between
January 2017 to December 2017. All files of patients with fungal
infections were analysed. The analysis of the data was done from
January 2018 to August 2018. Checklist was used to collect
information such as clinical diagnosis, age, name of antifungal,
number of antifungals, dosage form and dose frequency.
Descriptive analysis was done using STATA version 13.0.
Results: A total of 1,070 files of patients who attended Gynaecology
and Oncology Departments in the year 2017 were retrieved, of which 860 (80.4%) were from patients who attended Gynaecology
Department. A total of 156 (14.6%) files out of 1,070 were of
patients with fungal infections. Of the patients from gynaecology
116 (n=860, 13.48%) had fungal infection. While of the patients
from oncology 40 (n=210, 19.1%) had fungal infection. The most
common fungal infection diagnosed were vaginal candidiasis
112 (96.6%) and oral candidiasis 33 (82.5%) from gynaecology
and oncology department, respectively. Common antifungal
prescribed were azoles (clotrimazole 56.9% in gynaecology
and fluconazole 30% in oncology). The prevalence of irrational
antifungal prescription in gynaecology and oncology departments
was 22.4% (26/116) and 20% (8/40), respectively.
Conclusion: About one in five antifungal prescriptions for vaginal
candidiasis in gynaecology and oral candidiasis in oncology are
irrational as evidenced in standard treatment guideline. Clinicians
should adhere to the national standard treatment guidelines in
order to reduce irrational prescriptions of antifungal agents. |
| first_indexed | 2024-04-10T09:22:14Z |
| format | Article |
| id | doaj.art-7f8f3401bf3e449dbbed1f724243ee08 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T09:22:14Z |
| publishDate | 2022-08-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-7f8f3401bf3e449dbbed1f724243ee082023-02-20T09:19:24ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-08-01168QC06QC1010.7860/JCDR/2022/55087.1678Prescription Practices of Antifungal Agents at Gynaecology and Oncology Departments of a Tertiary Hospital in Mwanza, Tanzania: A Retrospective StudyKayo Hamasaki 0 Zaomba Hussein1Bernard Okamo2Stanley Mwita3Deogratius Katabaro4Stephen E Mshana5Martha F Mushi6Lecturer, School of Pharmacy, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.Student, School of Pharmacy, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.Lecturer, Department of Biochemistry and Molecular Biology, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.Lecturer, School of Pharmacy, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.Lecturer, School of Pharmacy, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.Professor, Department of Microbiology and Immunology, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.Senior Lecturer, Department of Microbiology and Immunology, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.Introduction: Irrational antifungals prescription results in inappropriate use of antifungals, leading to emergence of antifungal resistance. Aim: To determine the prescription patterns of antifungal agents in Gynaecology and Oncology Departments of the tertiary hospital in Tanzania. Materials and Methods: This was a retrospective hospital-based study involving files of patients who attended Gynaecology and Oncology Department of Bugando Medical Centre between January 2017 to December 2017. All files of patients with fungal infections were analysed. The analysis of the data was done from January 2018 to August 2018. Checklist was used to collect information such as clinical diagnosis, age, name of antifungal, number of antifungals, dosage form and dose frequency. Descriptive analysis was done using STATA version 13.0. Results: A total of 1,070 files of patients who attended Gynaecology and Oncology Departments in the year 2017 were retrieved, of which 860 (80.4%) were from patients who attended Gynaecology Department. A total of 156 (14.6%) files out of 1,070 were of patients with fungal infections. Of the patients from gynaecology 116 (n=860, 13.48%) had fungal infection. While of the patients from oncology 40 (n=210, 19.1%) had fungal infection. The most common fungal infection diagnosed were vaginal candidiasis 112 (96.6%) and oral candidiasis 33 (82.5%) from gynaecology and oncology department, respectively. Common antifungal prescribed were azoles (clotrimazole 56.9% in gynaecology and fluconazole 30% in oncology). The prevalence of irrational antifungal prescription in gynaecology and oncology departments was 22.4% (26/116) and 20% (8/40), respectively. Conclusion: About one in five antifungal prescriptions for vaginal candidiasis in gynaecology and oral candidiasis in oncology are irrational as evidenced in standard treatment guideline. Clinicians should adhere to the national standard treatment guidelines in order to reduce irrational prescriptions of antifungal agents.https://www.jcdr.net/articles/PDF/16786/55087_CE9AD)_F[SK]_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdfclotrimazolefluconazoleoral candidiasisvaginal candidiasis |
| spellingShingle | Kayo Hamasaki Zaomba Hussein Bernard Okamo Stanley Mwita Deogratius Katabaro Stephen E Mshana Martha F Mushi Prescription Practices of Antifungal Agents at Gynaecology and Oncology Departments of a Tertiary Hospital in Mwanza, Tanzania: A Retrospective Study Journal of Clinical and Diagnostic Research clotrimazole fluconazole oral candidiasis vaginal candidiasis |
| title | Prescription Practices of Antifungal Agents at Gynaecology and Oncology Departments of a Tertiary Hospital in Mwanza, Tanzania: A Retrospective Study |
| title_full | Prescription Practices of Antifungal Agents at Gynaecology and Oncology Departments of a Tertiary Hospital in Mwanza, Tanzania: A Retrospective Study |
| title_fullStr | Prescription Practices of Antifungal Agents at Gynaecology and Oncology Departments of a Tertiary Hospital in Mwanza, Tanzania: A Retrospective Study |
| title_full_unstemmed | Prescription Practices of Antifungal Agents at Gynaecology and Oncology Departments of a Tertiary Hospital in Mwanza, Tanzania: A Retrospective Study |
| title_short | Prescription Practices of Antifungal Agents at Gynaecology and Oncology Departments of a Tertiary Hospital in Mwanza, Tanzania: A Retrospective Study |
| title_sort | prescription practices of antifungal agents at gynaecology and oncology departments of a tertiary hospital in mwanza tanzania a retrospective study |
| topic | clotrimazole fluconazole oral candidiasis vaginal candidiasis |
| url | https://www.jcdr.net/articles/PDF/16786/55087_CE9AD)_F[SK]_PF1(AG_KM)_PFA(AG_KM)_PN(KM).pdf |
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