The Antibiotic Doxycycline Impairs Cardiac Mitochondrial and Contractile Function

The Antibiotic Doxycycline Impairs Cardiac Mitochondrial and Contractile Function

Tetracycline antibiotics act by inhibiting bacterial protein translation. Given the bacterial ancestry of mitochondria, we tested the hypothesis that doxycycline—which belongs to the tetracycline class—reduces mitochondrial function, and results in cardiac contractile dysfunction in cultured H9C2 ca...

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Bibliographic Details
Main Authors: Rob C. I. Wüst, Bram F. Coolen, Ntsiki M. Held, Mariah R. R. Daal, Vida Alizadeh Tazehkandi, Luciënne Baks-te Bulte, Marit Wiersma, Diederik W. D. Kuster, Bianca J. J. M. Brundel, Michel van Weeghel, Gustav J. Strijkers, Riekelt H. Houtkooper
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
doxycycline
mitochondrial function
cardiac contractility
calcium handling
Online Access:https://www.mdpi.com/1422-0067/22/8/4100

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