Intercepting biological messages: Antibacterial molecules targeting nucleic acids during interbacterial conflicts
Abstract Bacteria live in polymicrobial communities and constantly compete for resources. These organisms have evolved an array of antibacterial weapons to inhibit the growth or kill competitors. The arsenal comprises antibiotics, bacteriocins, and contact-dependent effectors that are either secrete...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2023-03-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000300104&lng=en&tlng=en |
| _version_ | 1827997658422181888 |
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| author | Julia Takuno Hespanhol Lior Karman Daniel Enrique Sanchez-Limache Ethel Bayer-Santos |
| author_facet | Julia Takuno Hespanhol Lior Karman Daniel Enrique Sanchez-Limache Ethel Bayer-Santos |
| author_sort | Julia Takuno Hespanhol |
| collection | DOAJ |
| description | Abstract Bacteria live in polymicrobial communities and constantly compete for resources. These organisms have evolved an array of antibacterial weapons to inhibit the growth or kill competitors. The arsenal comprises antibiotics, bacteriocins, and contact-dependent effectors that are either secreted in the medium or directly translocated into target cells. During bacterial antagonistic encounters, several cellular components important for life become a weak spot prone to an attack. Nucleic acids and the machinery responsible for their synthesis are well conserved across the tree of life. These molecules are part of the information flow in the central dogma of molecular biology and mediate long- and short-term storage for genetic information. The aim of this review is to summarize the diversity of antibacterial molecules that target nucleic acids during antagonistic interbacterial encounters and discuss their potential to promote the emergence antibiotic resistance. |
| first_indexed | 2024-04-10T05:31:25Z |
| format | Article |
| id | doaj.art-7f94169998a24400900ccdbc24cad96a |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-04-10T05:31:25Z |
| publishDate | 2023-03-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-7f94169998a24400900ccdbc24cad96a2023-03-07T07:33:02ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852023-03-01461 suppl 210.1590/1678-4685-gmb-2022-0266Intercepting biological messages: Antibacterial molecules targeting nucleic acids during interbacterial conflictsJulia Takuno Hespanholhttps://orcid.org/0000-0001-6701-7286Lior Karmanhttps://orcid.org/0000-0003-0702-5270Daniel Enrique Sanchez-Limachehttps://orcid.org/0000-0003-1364-7527Ethel Bayer-Santoshttps://orcid.org/0000-0003-3832-3449Abstract Bacteria live in polymicrobial communities and constantly compete for resources. These organisms have evolved an array of antibacterial weapons to inhibit the growth or kill competitors. The arsenal comprises antibiotics, bacteriocins, and contact-dependent effectors that are either secreted in the medium or directly translocated into target cells. During bacterial antagonistic encounters, several cellular components important for life become a weak spot prone to an attack. Nucleic acids and the machinery responsible for their synthesis are well conserved across the tree of life. These molecules are part of the information flow in the central dogma of molecular biology and mediate long- and short-term storage for genetic information. The aim of this review is to summarize the diversity of antibacterial molecules that target nucleic acids during antagonistic interbacterial encounters and discuss their potential to promote the emergence antibiotic resistance.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000300104&lng=en&tlng=enAntibioticsbacteriocinseffectorsDNaseRNase |
| spellingShingle | Julia Takuno Hespanhol Lior Karman Daniel Enrique Sanchez-Limache Ethel Bayer-Santos Intercepting biological messages: Antibacterial molecules targeting nucleic acids during interbacterial conflicts Genetics and Molecular Biology Antibiotics bacteriocins effectors DNase RNase |
| title | Intercepting biological messages: Antibacterial molecules targeting nucleic acids during interbacterial conflicts |
| title_full | Intercepting biological messages: Antibacterial molecules targeting nucleic acids during interbacterial conflicts |
| title_fullStr | Intercepting biological messages: Antibacterial molecules targeting nucleic acids during interbacterial conflicts |
| title_full_unstemmed | Intercepting biological messages: Antibacterial molecules targeting nucleic acids during interbacterial conflicts |
| title_short | Intercepting biological messages: Antibacterial molecules targeting nucleic acids during interbacterial conflicts |
| title_sort | intercepting biological messages antibacterial molecules targeting nucleic acids during interbacterial conflicts |
| topic | Antibiotics bacteriocins effectors DNase RNase |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572023000300104&lng=en&tlng=en |
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