Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation
The influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial design 3². Gastrointestinal tolerance following oral administration in rats...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2006-10-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000500019&lng=en&tlng=en |
| _version_ | 1818041795194388480 |
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| author | Ruy Carlos R. Beck Sandra Elisa Haas Silvia Stanisçuaski Guterres Maria Inês Ré Edilson V. Benvenutti Adriana Raffin Pohlmann |
| author_facet | Ruy Carlos R. Beck Sandra Elisa Haas Silvia Stanisçuaski Guterres Maria Inês Ré Edilson V. Benvenutti Adriana Raffin Pohlmann |
| author_sort | Ruy Carlos R. Beck |
| collection | DOAJ |
| description | The influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial design 3². Gastrointestinal tolerance following oral administration in rats was evaluated. Formulations were selected considering the best yields, the best encapsulation efficiencies and the lowest water contents, presenting surfaces completely coated by nanostructures and a decrease in the surface areas in relation to the uncoated core. In vitro drug release demonstrated the influence of the nanoparticle-coating on the dissolution profiles of diclofenac. Nanocapsule-coated microparticles presented a protective effect on the gastrointestinal mucosa. |
| first_indexed | 2024-12-10T08:36:06Z |
| format | Article |
| id | doaj.art-7f942f6275b845bd8686c7a07bb911e1 |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-12-10T08:36:06Z |
| publishDate | 2006-10-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-7f942f6275b845bd8686c7a07bb911e12022-12-22T01:55:58ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642006-10-0129599099610.1590/S0100-40422006000500019S0100-40422006000500019Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluationRuy Carlos R. Beck0Sandra Elisa Haas1Silvia Stanisçuaski Guterres2Maria Inês Ré3Edilson V. Benvenutti4Adriana Raffin Pohlmann5Universidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulInstituto de Pesquisas Tecnológicas do Estado de São PauloUniversidade Federal do Rio Grande do SulUniversidade Federal do Rio Grande do SulThe influences of the spray-drying parameters and the type of nanoparticles (nanocapsules or nanospheres) on the characteristics of nanoparticle-coated diclofenac-loaded microparticles were investigated by using a factorial design 3². Gastrointestinal tolerance following oral administration in rats was evaluated. Formulations were selected considering the best yields, the best encapsulation efficiencies and the lowest water contents, presenting surfaces completely coated by nanostructures and a decrease in the surface areas in relation to the uncoated core. In vitro drug release demonstrated the influence of the nanoparticle-coating on the dissolution profiles of diclofenac. Nanocapsule-coated microparticles presented a protective effect on the gastrointestinal mucosa.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000500019&lng=en&tlng=ennanocoatingnanoparticlemicroparticle |
| spellingShingle | Ruy Carlos R. Beck Sandra Elisa Haas Silvia Stanisçuaski Guterres Maria Inês Ré Edilson V. Benvenutti Adriana Raffin Pohlmann Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation Química Nova nanocoating nanoparticle microparticle |
| title | Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation |
| title_full | Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation |
| title_fullStr | Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation |
| title_full_unstemmed | Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation |
| title_short | Nanoparticle-coated organic-inorganic microparticles: experimental design and gastrointestinal tolerance evaluation |
| title_sort | nanoparticle coated organic inorganic microparticles experimental design and gastrointestinal tolerance evaluation |
| topic | nanocoating nanoparticle microparticle |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422006000500019&lng=en&tlng=en |
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