Identification of the Antibacterial Compound Produced by the Marine Epiphytic Bacterium Pseudovibrio sp. D323 and Related Sponge-Associated Bacteria
Surface-associated marine bacteria often produce secondary metabolites with antagonistic activities. In this study, tropodithietic acid (TDA) was identified to be responsible for the antibacterial activity of the marine epiphytic bacterium Pseudovibrio sp. D323 and related strains. Phenol was also p...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2011-08-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/9/8/1391/ |
| _version_ | 1828145884348547072 |
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| author | Suhelen Egan Anahit Penesyan Tilmann Harder Matthew Lee Torsten Thomas Staffan Kjelleberg Jan Tebben |
| author_facet | Suhelen Egan Anahit Penesyan Tilmann Harder Matthew Lee Torsten Thomas Staffan Kjelleberg Jan Tebben |
| author_sort | Suhelen Egan |
| collection | DOAJ |
| description | Surface-associated marine bacteria often produce secondary metabolites with antagonistic activities. In this study, tropodithietic acid (TDA) was identified to be responsible for the antibacterial activity of the marine epiphytic bacterium Pseudovibrio sp. D323 and related strains. Phenol was also produced by these bacteria but was not directly related to the antibacterial activity. TDA was shown to effectively inhibit a range of marine bacteria from various phylogenetic groups. However TDA-producers themselves were resistant and are likely to possess resistance mechanism preventing autoinhibition. We propose that TDA in isolate D323 and related eukaryote-associated bacteria plays a role in defending the host organism against unwanted microbial colonisation and, possibly, bacterial pathogens. |
| first_indexed | 2024-04-11T20:38:57Z |
| format | Article |
| id | doaj.art-7f95c323184649988c2519418c1331ba |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T20:38:57Z |
| publishDate | 2011-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-7f95c323184649988c2519418c1331ba2022-12-22T04:04:16ZengMDPI AGMarine Drugs1660-33972011-08-01981391140210.3390/md9081391Identification of the Antibacterial Compound Produced by the Marine Epiphytic Bacterium Pseudovibrio sp. D323 and Related Sponge-Associated BacteriaSuhelen EganAnahit PenesyanTilmann HarderMatthew LeeTorsten ThomasStaffan KjellebergJan TebbenSurface-associated marine bacteria often produce secondary metabolites with antagonistic activities. In this study, tropodithietic acid (TDA) was identified to be responsible for the antibacterial activity of the marine epiphytic bacterium Pseudovibrio sp. D323 and related strains. Phenol was also produced by these bacteria but was not directly related to the antibacterial activity. TDA was shown to effectively inhibit a range of marine bacteria from various phylogenetic groups. However TDA-producers themselves were resistant and are likely to possess resistance mechanism preventing autoinhibition. We propose that TDA in isolate D323 and related eukaryote-associated bacteria plays a role in defending the host organism against unwanted microbial colonisation and, possibly, bacterial pathogens.http://www.mdpi.com/1660-3397/9/8/1391/marine bacteriabioactiveantimicrobialsymbiosistropodithietic acid |
| spellingShingle | Suhelen Egan Anahit Penesyan Tilmann Harder Matthew Lee Torsten Thomas Staffan Kjelleberg Jan Tebben Identification of the Antibacterial Compound Produced by the Marine Epiphytic Bacterium Pseudovibrio sp. D323 and Related Sponge-Associated Bacteria Marine Drugs marine bacteria bioactive antimicrobial symbiosis tropodithietic acid |
| title | Identification of the Antibacterial Compound Produced by the Marine Epiphytic Bacterium Pseudovibrio sp. D323 and Related Sponge-Associated Bacteria |
| title_full | Identification of the Antibacterial Compound Produced by the Marine Epiphytic Bacterium Pseudovibrio sp. D323 and Related Sponge-Associated Bacteria |
| title_fullStr | Identification of the Antibacterial Compound Produced by the Marine Epiphytic Bacterium Pseudovibrio sp. D323 and Related Sponge-Associated Bacteria |
| title_full_unstemmed | Identification of the Antibacterial Compound Produced by the Marine Epiphytic Bacterium Pseudovibrio sp. D323 and Related Sponge-Associated Bacteria |
| title_short | Identification of the Antibacterial Compound Produced by the Marine Epiphytic Bacterium Pseudovibrio sp. D323 and Related Sponge-Associated Bacteria |
| title_sort | identification of the antibacterial compound produced by the marine epiphytic bacterium pseudovibrio sp d323 and related sponge associated bacteria |
| topic | marine bacteria bioactive antimicrobial symbiosis tropodithietic acid |
| url | http://www.mdpi.com/1660-3397/9/8/1391/ |
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