Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle

Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle

The molecular mechanisms by which aging affects stem cell number and function are poorly understood. Murine data have implicated cellular senescence in the loss of muscle stem cells with aging. Here, using human cells and by carrying out experiments within a strictly pre-senescent division count, we...

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Bibliographic Details
Main Authors: Anne Bigot, William J. Duddy, Zamalou G. Ouandaogo, Elisa Negroni, Virginie Mariot, Svetlana Ghimbovschi, Brennan Harmon, Aurore Wielgosik, Camille Loiseau, Joe Devaney, Julie Dumonceaux, Gillian Butler-Browne, Vincent Mouly, Stéphanie Duguez
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Cell Reports
Subjects:
aging
DNA methylation
human muscle stem cell
myoblast
quiescence
sprouty1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715011092

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