Correlation between Apolipoprotein B/Apolipoprotein A-I Ratio with Atherogenic Index of Plasma among Acute Myocardial Infarction Patients
BACKGROUND: Acute myocardial infarction (AMI) is the most common cause of death in the world. One preventive attempt to reduce AMI is early detection of blood lipid profile. A simple method of lipid profile assessment is the measurement of atherogenic index of plasma (AIP), meanwhile more accurate m...
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| Format: | Article |
| Language: | English |
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Secretariat of The Indonesian Biomedical Journal
2018-08-01
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| Series: | Indonesian Biomedical Journal |
| Online Access: | https://inabj.org/index.php/ibj/article/view/400 |
| _version_ | 1811287885960183808 |
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| author | Winardi Emmanuel Setiawan Anggoro Budi Hartopo Royhan Rozqie |
| author_facet | Winardi Emmanuel Setiawan Anggoro Budi Hartopo Royhan Rozqie |
| author_sort | Winardi Emmanuel Setiawan |
| collection | DOAJ |
| description | BACKGROUND: Acute myocardial infarction (AMI) is the most common cause of death in the world. One preventive attempt to reduce AMI is early detection of blood lipid profile. A simple method of lipid profile assessment is the measurement of atherogenic index of plasma (AIP), meanwhile more accurate method of lipid profile assessment is the measurement of apolipoprotein B/apolipoprotien A-I (ApoB/ApoAI) ratio. However, whether both measurements are interchangeable is need to be investigated. This study aims to investigate the correlation between AIP value and ApoB/ApoAI ratio in patients with AMI.
METHODS: The study design was cross-sectional study. The blood samples of consecutively enrolled AMI patients had been selected after inclusion and exclusion criteria. The blood samples were taken within 24 hours of patient admission to the hospital. The blood concentration of high-density lipoprotein (HDL) and triglycerides (TG) were measured using turbidimetric method. The AIP was calculated as logarithmic of TG/HDL ratio (log10.[TG:HDL]) The concentration of ApoB and ApoAI were measured using immunoturbidimetric method. The correlation between these measurements was analyzed with Pearson correlation test.
RESULTS: The blood samples of 76 subjects were collected and analyzed. The subjects were dominated by male (n=67, 88%) and those whose age ≥55 years old (n=54, 71%). The mean ApoB value was 88.66 mg/dL and ApoAI was 97.39 mg/dL. The AIP value was 0.05. The Pearson correlation test between AIP and ApoB/ApoAI ratio showed a significant positive correlation with the strength of correlation was moderate (r=0.51, p-value<0.01).
CONCLUSION: There was a significantly positive and moderate correlation between AIP value and ApoB/ApoAI ratio in acute myocardial infarction patients.
KEYWORDS: atherogenic index of plasma, acute myocardial infarction, apolipoprotein B/apolipoprotein A-I ratio |
| first_indexed | 2024-04-13T03:26:20Z |
| format | Article |
| id | doaj.art-7f9775141bee43ca96331be9b43b3cc0 |
| institution | Directory Open Access Journal |
| issn | 2085-3297 2355-9179 |
| language | English |
| last_indexed | 2024-04-13T03:26:20Z |
| publishDate | 2018-08-01 |
| publisher | Secretariat of The Indonesian Biomedical Journal |
| record_format | Article |
| series | Indonesian Biomedical Journal |
| spelling | doaj.art-7f9775141bee43ca96331be9b43b3cc02022-12-22T03:04:38ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792018-08-011021798310.18585/inabj.v10i2.400272Correlation between Apolipoprotein B/Apolipoprotein A-I Ratio with Atherogenic Index of Plasma among Acute Myocardial Infarction PatientsWinardi Emmanuel Setiawan0Anggoro Budi Hartopo1Royhan Rozqie2Undergraduate Study Program on Medicine, Faculty of Medicine, Universitas Gadjah Mada, Jl. Farmako Sekip Utara,YogyakartaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Gadjah Mada – Dr. Sardjito Hospital, Jl. Farmako Sekip Utara, YogyakartaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Gadjah Mada – Dr. Sardjito Hospital, Jl. Farmako Sekip Utara, YogyakartaBACKGROUND: Acute myocardial infarction (AMI) is the most common cause of death in the world. One preventive attempt to reduce AMI is early detection of blood lipid profile. A simple method of lipid profile assessment is the measurement of atherogenic index of plasma (AIP), meanwhile more accurate method of lipid profile assessment is the measurement of apolipoprotein B/apolipoprotien A-I (ApoB/ApoAI) ratio. However, whether both measurements are interchangeable is need to be investigated. This study aims to investigate the correlation between AIP value and ApoB/ApoAI ratio in patients with AMI. METHODS: The study design was cross-sectional study. The blood samples of consecutively enrolled AMI patients had been selected after inclusion and exclusion criteria. The blood samples were taken within 24 hours of patient admission to the hospital. The blood concentration of high-density lipoprotein (HDL) and triglycerides (TG) were measured using turbidimetric method. The AIP was calculated as logarithmic of TG/HDL ratio (log10.[TG:HDL]) The concentration of ApoB and ApoAI were measured using immunoturbidimetric method. The correlation between these measurements was analyzed with Pearson correlation test. RESULTS: The blood samples of 76 subjects were collected and analyzed. The subjects were dominated by male (n=67, 88%) and those whose age ≥55 years old (n=54, 71%). The mean ApoB value was 88.66 mg/dL and ApoAI was 97.39 mg/dL. The AIP value was 0.05. The Pearson correlation test between AIP and ApoB/ApoAI ratio showed a significant positive correlation with the strength of correlation was moderate (r=0.51, p-value<0.01). CONCLUSION: There was a significantly positive and moderate correlation between AIP value and ApoB/ApoAI ratio in acute myocardial infarction patients. KEYWORDS: atherogenic index of plasma, acute myocardial infarction, apolipoprotein B/apolipoprotein A-I ratiohttps://inabj.org/index.php/ibj/article/view/400 |
| spellingShingle | Winardi Emmanuel Setiawan Anggoro Budi Hartopo Royhan Rozqie Correlation between Apolipoprotein B/Apolipoprotein A-I Ratio with Atherogenic Index of Plasma among Acute Myocardial Infarction Patients Indonesian Biomedical Journal |
| title | Correlation between Apolipoprotein B/Apolipoprotein A-I Ratio with Atherogenic Index of Plasma among Acute Myocardial Infarction Patients |
| title_full | Correlation between Apolipoprotein B/Apolipoprotein A-I Ratio with Atherogenic Index of Plasma among Acute Myocardial Infarction Patients |
| title_fullStr | Correlation between Apolipoprotein B/Apolipoprotein A-I Ratio with Atherogenic Index of Plasma among Acute Myocardial Infarction Patients |
| title_full_unstemmed | Correlation between Apolipoprotein B/Apolipoprotein A-I Ratio with Atherogenic Index of Plasma among Acute Myocardial Infarction Patients |
| title_short | Correlation between Apolipoprotein B/Apolipoprotein A-I Ratio with Atherogenic Index of Plasma among Acute Myocardial Infarction Patients |
| title_sort | correlation between apolipoprotein b apolipoprotein a i ratio with atherogenic index of plasma among acute myocardial infarction patients |
| url | https://inabj.org/index.php/ibj/article/view/400 |
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