Diversity of Solid Forms Promoted by Ball Milling: Characterization and Intrinsic Dissolution Studies of Pioglitazone Hydrochloride and Fluvastatin Sodium Drug–Drug Systems

Diversity of Solid Forms Promoted by Ball Milling: Characterization and Intrinsic Dissolution Studies of Pioglitazone Hydrochloride and Fluvastatin Sodium Drug–Drug Systems

Coamorphous salt in a 1:1 ratio prepared by ball milling from Fluvastatin sodium (FLV) and Pioglitazone hydrochloride (PGZ·HCl) can be selectively formed by neat grinding (NG). Furthermore, the salt–cocrystal continuum was preferably formed by employing liquid-assisted grinding (LAG) using ethanol (...

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Bibliographic Details
Main Authors: Marco Villeda-Villegas, José C. Páez-Franco, Guadalupe Coyote-Dotor, Alejandra Núñez-Pineda, Alejandro Dorazco-González, Inés Fuentes-Noriega, Kenneth Rubio-Carrasco, Helen P. Toledo Jaldín, David Morales-Morales, Juan Manuel Germán-Acacio
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Pharmaceuticals
Subjects:
drug–drug coamorphous
drug–drug salt–cocrystal continuum
mechanochemical reactions
intrinsic dissolution experiments
fluvastatin sodium
pioglitazone hydrochloride
Online Access:https://www.mdpi.com/1424-8247/16/6/781

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