What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation
Myosin II and its regulator Rho-associated coiled-coil containing protein kinase (ROCK) are essential for cell invasion and metastatic dissemination. Our recent findings show that this molecular machinery is also involved in drug resistance in melanoma by playing a dual role: protection of tumor cel...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-05-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2020.1735911 |
| _version_ | 1797677151731843072 |
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| author | Jose L Orgaz Victoria Sanz-Moreno |
| author_facet | Jose L Orgaz Victoria Sanz-Moreno |
| author_sort | Jose L Orgaz |
| collection | DOAJ |
| description | Myosin II and its regulator Rho-associated coiled-coil containing protein kinase (ROCK) are essential for cell invasion and metastatic dissemination. Our recent findings show that this molecular machinery is also involved in drug resistance in melanoma by playing a dual role: protection of tumor cells from reactive oxygen species (ROS) and DNA damage (intrinsic), and co-option of myeloid and lymphoid populations to establish immunosuppression (extrinsic). |
| first_indexed | 2024-03-11T22:40:49Z |
| format | Article |
| id | doaj.art-7f997344a0564fe9b058fff5a433b77e |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:49Z |
| publishDate | 2020-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-7f997344a0564fe9b058fff5a433b77e2023-09-22T09:11:01ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562020-05-017310.1080/23723556.2020.17359111735911What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivationJose L Orgaz0Victoria Sanz-Moreno1Queen Mary University of London, John Vane Science BuildingQueen Mary University of London, John Vane Science BuildingMyosin II and its regulator Rho-associated coiled-coil containing protein kinase (ROCK) are essential for cell invasion and metastatic dissemination. Our recent findings show that this molecular machinery is also involved in drug resistance in melanoma by playing a dual role: protection of tumor cells from reactive oxygen species (ROS) and DNA damage (intrinsic), and co-option of myeloid and lymphoid populations to establish immunosuppression (extrinsic).http://dx.doi.org/10.1080/23723556.2020.1735911myosin iicytoskeletal remodelingmelanoma therapy resistancetranscriptional rewiringimmunotherapy |
| spellingShingle | Jose L Orgaz Victoria Sanz-Moreno What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation Molecular & Cellular Oncology myosin ii cytoskeletal remodeling melanoma therapy resistance transcriptional rewiring immunotherapy |
| title | What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation |
| title_full | What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation |
| title_fullStr | What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation |
| title_full_unstemmed | What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation |
| title_short | What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation |
| title_sort | what does not kill you makes you stronger surviving anti cancer therapies by cytoskeletal remodeling and myosin ii reactivation |
| topic | myosin ii cytoskeletal remodeling melanoma therapy resistance transcriptional rewiring immunotherapy |
| url | http://dx.doi.org/10.1080/23723556.2020.1735911 |
| work_keys_str_mv | AT joselorgaz whatdoesnotkillyoumakesyoustrongersurvivinganticancertherapiesbycytoskeletalremodelingandmyosiniireactivation AT victoriasanzmoreno whatdoesnotkillyoumakesyoustrongersurvivinganticancertherapiesbycytoskeletalremodelingandmyosiniireactivation |