In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl)thiazole compounds

In silico ADMET prediction, evaluation of cytotoxicity in mouse splenocytes and preliminary evaluation of in vitro antimalarial activity of 4-(4-chlorophenyl)thiazole compounds

Abstract In this work, an in silico study and evaluation of the cytotoxicity of 4-(4-chlorophenyl)thiazole compounds against mouse splenocytes and the chloroquine-sensitive Plasmodium falciparum 3D7 strain are reported. The in silico results showed that the compounds have important pharmacokinetic p...

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Bibliographic Details
Main Authors:	BEATRIZ R.M.G. DA SILVA, NATANAEL DA SILVA BEZERRA JÚNIOR, JAMERSON F. DE OLIVEIRA, DENISE MARIA F.A. DUARTE, DIEGO S.C. MARQUES, FÁTIMA NOGUEIRA, MARIA CARMO A. DE LIMA, IRANILDO JOSÉ DA CRUZ FILHO
Format:	Article
Language:	English
Published:	Academia Brasileira de Ciências 2023-12-01
Series:	Anais da Academia Brasileira de Ciências
Subjects:	thiazoles ADMET mammalian cell cytotoxicity antimalarial activity
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652023000500602&lng=en&tlng=en

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