Astrocytes in Neurodegeneration: Inspiration From Genetics
Despite the discovery of numerous molecules and pathologies, the pathophysiology of various neurodegenerative diseases remains unknown. Genetics participates in the pathogenesis of neurodegeneration. Neural dysfunction, which is thought to be a cell-autonomous mechanism, is insufficient to explain t...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.882316/full |
| _version_ | 1828325666609692672 |
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| author | Jingxuan Huang Chunyu Li Huifang Shang |
| author_facet | Jingxuan Huang Chunyu Li Huifang Shang |
| author_sort | Jingxuan Huang |
| collection | DOAJ |
| description | Despite the discovery of numerous molecules and pathologies, the pathophysiology of various neurodegenerative diseases remains unknown. Genetics participates in the pathogenesis of neurodegeneration. Neural dysfunction, which is thought to be a cell-autonomous mechanism, is insufficient to explain the development of neurodegenerative disease, implying that other cells surrounding or related to neurons, such as glial cells, are involved in the pathogenesis. As the primary component of glial cells, astrocytes play a variety of roles in the maintenance of physiological functions in neurons and other glial cells. The pathophysiology of neurodegeneration is also influenced by reactive astrogliosis in response to central nervous system (CNS) injuries. Furthermore, those risk-gene variants identified in neurodegenerations are involved in astrocyte activation and senescence. In this review, we summarized the relationships between gene variants and astrocytes in four neurodegenerative diseases, including Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Parkinson’s disease (PD), and provided insights into the implications of astrocytes in the neurodegenerations. |
| first_indexed | 2024-04-13T19:25:43Z |
| format | Article |
| id | doaj.art-7f9a7b99d6214e2aae44773d33d25446 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T19:25:43Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-7f9a7b99d6214e2aae44773d33d254462022-12-22T02:33:22ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-06-011610.3389/fnins.2022.882316882316Astrocytes in Neurodegeneration: Inspiration From GeneticsJingxuan HuangChunyu LiHuifang ShangDespite the discovery of numerous molecules and pathologies, the pathophysiology of various neurodegenerative diseases remains unknown. Genetics participates in the pathogenesis of neurodegeneration. Neural dysfunction, which is thought to be a cell-autonomous mechanism, is insufficient to explain the development of neurodegenerative disease, implying that other cells surrounding or related to neurons, such as glial cells, are involved in the pathogenesis. As the primary component of glial cells, astrocytes play a variety of roles in the maintenance of physiological functions in neurons and other glial cells. The pathophysiology of neurodegeneration is also influenced by reactive astrogliosis in response to central nervous system (CNS) injuries. Furthermore, those risk-gene variants identified in neurodegenerations are involved in astrocyte activation and senescence. In this review, we summarized the relationships between gene variants and astrocytes in four neurodegenerative diseases, including Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and Parkinson’s disease (PD), and provided insights into the implications of astrocytes in the neurodegenerations.https://www.frontiersin.org/articles/10.3389/fnins.2022.882316/fullastrocyteneurodegenerationgene variantADALSPD |
| spellingShingle | Jingxuan Huang Chunyu Li Huifang Shang Astrocytes in Neurodegeneration: Inspiration From Genetics Frontiers in Neuroscience astrocyte neurodegeneration gene variant AD ALS PD |
| title | Astrocytes in Neurodegeneration: Inspiration From Genetics |
| title_full | Astrocytes in Neurodegeneration: Inspiration From Genetics |
| title_fullStr | Astrocytes in Neurodegeneration: Inspiration From Genetics |
| title_full_unstemmed | Astrocytes in Neurodegeneration: Inspiration From Genetics |
| title_short | Astrocytes in Neurodegeneration: Inspiration From Genetics |
| title_sort | astrocytes in neurodegeneration inspiration from genetics |
| topic | astrocyte neurodegeneration gene variant AD ALS PD |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.882316/full |
| work_keys_str_mv | AT jingxuanhuang astrocytesinneurodegenerationinspirationfromgenetics AT chunyuli astrocytesinneurodegenerationinspirationfromgenetics AT huifangshang astrocytesinneurodegenerationinspirationfromgenetics |