DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain

DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain

Background/Aims: The linoleic acid derivative DCP-LA selectively and directly activates PKCε. The present study aimed at understanding the mechanism of DCP-LA-induced PKCε activation. Methods: Point mutation in the C2-like domain on PKCε was carried out, and each kinase activity was monitored in PC-...

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Bibliographic Details
Main Authors: Takeshi Kanno, Ayako Tsuchiya, Tadashi Shimizu, Miyuki Mabuchi, Akito Tanaka, Tomoyuki Nishizaki
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
PKCε
C2-like domain
Phosphatidylserine binding/associating sites
Direct interaction
DCP-LA
Online Access:http://www.karger.com/Article/FullText/430344

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