MRI-Visible Perivascular Spaces Associated With Cognitive Impairment in Military Veterans With Traumatic Brain Injury Mediated by CSF P-Tau
ObjectiveTo investigate the association of MRI-visible perivascular spaces (PVS) with cognitive impairment in military veterans with traumatic brain injury (TBI), and whether cerebrospinal fluid (CSF) p-tau and Aβ mediate this effect.Materials and MethodsWe included 55 Vietnam War veterans with a hi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.921203/full |
| _version_ | 1811316041996828672 |
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| author | Ming-Liang Wang Dian-Xu Yang Zheng Sun Wen-Bin Li Qiao-Qiao Zou Peng-Yang Li Xue Wu Yue-Hua Li |
| author_facet | Ming-Liang Wang Dian-Xu Yang Zheng Sun Wen-Bin Li Qiao-Qiao Zou Peng-Yang Li Xue Wu Yue-Hua Li |
| author_sort | Ming-Liang Wang |
| collection | DOAJ |
| description | ObjectiveTo investigate the association of MRI-visible perivascular spaces (PVS) with cognitive impairment in military veterans with traumatic brain injury (TBI), and whether cerebrospinal fluid (CSF) p-tau and Aβ mediate this effect.Materials and MethodsWe included 55 Vietnam War veterans with a history of TBI and 52 non-TBI Vietnam War veterans from the Department of Defense Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. All the subjects had brain MRI, CSF p-tau, Aβ, and neuropsychological examinations. MRI-visible PVS number and grade were rated on MRI in the centrum semiovale (CSO-PVS) and basal ganglia (BG-PVS). Multiple linear regression was performed to assess the association between MRI-visible PVS and cognitive impairment and the interaction effect of TBI. Additionally, mediation effect of CSF biomarkers on the relationship between MRI-visible PVS and cognitive impairment was explored in TBI group.ResultsCompared with military control, TBI group had higher CSO-PVS number (p = 0.001), CSF p-tau (p = 0.022) and poorer performance in verbal memory (p = 0.022). High CSO-PVS number was associated with poor verbal memory in TBI group (β = -0.039, 95% CI −0.062, −0.016), but not in military control group (β = 0.019, 95% CI −0.004, 0.043) (p-interaction = 0.003). Further mediation analysis revealed that CSF p-tau had a significant indirect effect (β = −0.009, 95% CI: −0.022 −0.001, p = 0.001) and mediated 18.75% effect for the relationship between CSO-PVS and verbal memory in TBI group.ConclusionMRI-visible CSO-PVS was more common in Vietnam War veterans with a history of TBI and was associated with poor verbal memory, mediated partially by CSF p-tau. |
| first_indexed | 2024-04-13T11:41:55Z |
| format | Article |
| id | doaj.art-7f9d250de8f2401aacfc2d9506504051 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-13T11:41:55Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-7f9d250de8f2401aacfc2d95065040512022-12-22T02:48:17ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402022-07-011310.3389/fpsyt.2022.921203921203MRI-Visible Perivascular Spaces Associated With Cognitive Impairment in Military Veterans With Traumatic Brain Injury Mediated by CSF P-TauMing-Liang Wang0Dian-Xu Yang1Zheng Sun2Wen-Bin Li3Qiao-Qiao Zou4Peng-Yang Li5Xue Wu6Yue-Hua Li7Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaDepartment of Neurosurgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaDepartment of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaDepartment of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaDepartment of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaDivision of Cardiology, Pauley Heart Center, Virginia Commonwealth University, Richmond, VA, United StatesInstitute for Global Health Sciences, University of California, San Francisco, San Francisco, CA, United StatesDepartment of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, ChinaObjectiveTo investigate the association of MRI-visible perivascular spaces (PVS) with cognitive impairment in military veterans with traumatic brain injury (TBI), and whether cerebrospinal fluid (CSF) p-tau and Aβ mediate this effect.Materials and MethodsWe included 55 Vietnam War veterans with a history of TBI and 52 non-TBI Vietnam War veterans from the Department of Defense Alzheimer’s Disease Neuroimaging Initiative (ADNI) database. All the subjects had brain MRI, CSF p-tau, Aβ, and neuropsychological examinations. MRI-visible PVS number and grade were rated on MRI in the centrum semiovale (CSO-PVS) and basal ganglia (BG-PVS). Multiple linear regression was performed to assess the association between MRI-visible PVS and cognitive impairment and the interaction effect of TBI. Additionally, mediation effect of CSF biomarkers on the relationship between MRI-visible PVS and cognitive impairment was explored in TBI group.ResultsCompared with military control, TBI group had higher CSO-PVS number (p = 0.001), CSF p-tau (p = 0.022) and poorer performance in verbal memory (p = 0.022). High CSO-PVS number was associated with poor verbal memory in TBI group (β = -0.039, 95% CI −0.062, −0.016), but not in military control group (β = 0.019, 95% CI −0.004, 0.043) (p-interaction = 0.003). Further mediation analysis revealed that CSF p-tau had a significant indirect effect (β = −0.009, 95% CI: −0.022 −0.001, p = 0.001) and mediated 18.75% effect for the relationship between CSO-PVS and verbal memory in TBI group.ConclusionMRI-visible CSO-PVS was more common in Vietnam War veterans with a history of TBI and was associated with poor verbal memory, mediated partially by CSF p-tau.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.921203/fulltraumatic brain injuryMRICSFtauAβMRI-visible perivascular spaces |
| spellingShingle | Ming-Liang Wang Dian-Xu Yang Zheng Sun Wen-Bin Li Qiao-Qiao Zou Peng-Yang Li Xue Wu Yue-Hua Li MRI-Visible Perivascular Spaces Associated With Cognitive Impairment in Military Veterans With Traumatic Brain Injury Mediated by CSF P-Tau Frontiers in Psychiatry traumatic brain injury MRI CSF tau Aβ MRI-visible perivascular spaces |
| title | MRI-Visible Perivascular Spaces Associated With Cognitive Impairment in Military Veterans With Traumatic Brain Injury Mediated by CSF P-Tau |
| title_full | MRI-Visible Perivascular Spaces Associated With Cognitive Impairment in Military Veterans With Traumatic Brain Injury Mediated by CSF P-Tau |
| title_fullStr | MRI-Visible Perivascular Spaces Associated With Cognitive Impairment in Military Veterans With Traumatic Brain Injury Mediated by CSF P-Tau |
| title_full_unstemmed | MRI-Visible Perivascular Spaces Associated With Cognitive Impairment in Military Veterans With Traumatic Brain Injury Mediated by CSF P-Tau |
| title_short | MRI-Visible Perivascular Spaces Associated With Cognitive Impairment in Military Veterans With Traumatic Brain Injury Mediated by CSF P-Tau |
| title_sort | mri visible perivascular spaces associated with cognitive impairment in military veterans with traumatic brain injury mediated by csf p tau |
| topic | traumatic brain injury MRI CSF tau Aβ MRI-visible perivascular spaces |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.921203/full |
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