Cold atmospheric plasma increases IBRV titer in MDBK cells by orchestrating the host cell network
Enhancing virus multiplication could assist in the rapid production of vaccines against viral diseases. Cold atmospheric plasma (CAP), a physical approach relying on reactive oxygen species to achieve the desirable cellular outcome, was shown to be effective in enhancing virus propagation, where bov...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-12-01
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| Series: | Virulence |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21505594.2021.1883933 |
| _version_ | 1828125635500834816 |
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| author | Yujie Miao Peiyu Han Dong Hua Renwu Zhou Zhengbing Guan Qing Lv Xiaofeng Dai |
| author_facet | Yujie Miao Peiyu Han Dong Hua Renwu Zhou Zhengbing Guan Qing Lv Xiaofeng Dai |
| author_sort | Yujie Miao |
| collection | DOAJ |
| description | Enhancing virus multiplication could assist in the rapid production of vaccines against viral diseases. Cold atmospheric plasma (CAP), a physical approach relying on reactive oxygen species to achieve the desirable cellular outcome, was shown to be effective in enhancing virus propagation, where bovine rhinotrachieitis virus and Madin-Darby Bovine Kidney cells were used as the modeling virus and cell line, respectively. CAP was shown to create synergies with virus infection in arresting host cells at the G2/M stage, decreasing cell membrane potential, increasing intracellular calcium level, and inducing selective autophagy. In addition, CAP was demonstrated to suppress virus-triggered immunogenic signaling as evaluated by IRF7 expression. We presented evidences on CAP-triggered maximization of host resources toward virus multiplication that is advantageous for viral vaccine production, and opened a novel regime for applying CAP in the sector of medical care and health. |
| first_indexed | 2024-04-11T15:23:34Z |
| format | Article |
| id | doaj.art-7f9e217568814e5fa4fa7d771cd03a66 |
| institution | Directory Open Access Journal |
| issn | 2150-5594 2150-5608 |
| language | English |
| last_indexed | 2024-04-11T15:23:34Z |
| publishDate | 2021-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Virulence |
| spelling | doaj.art-7f9e217568814e5fa4fa7d771cd03a662022-12-22T04:16:18ZengTaylor & Francis GroupVirulence2150-55942150-56082021-12-0112167968910.1080/21505594.2021.18839331883933Cold atmospheric plasma increases IBRV titer in MDBK cells by orchestrating the host cell networkYujie Miao0Peiyu Han1Dong Hua2Renwu Zhou3Zhengbing Guan4Qing Lv5Xiaofeng Dai6The Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan UniversityWuxi School of Medicine, Jiangnan UniversityAffiliated Hospital of Jiangnan UniversitySchool of Chemical and Biomolecular Engineering, University of SydneyThe Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan UniversityAffiliated Hospital of Jiangnan UniversityWuxi School of Medicine, Jiangnan UniversityEnhancing virus multiplication could assist in the rapid production of vaccines against viral diseases. Cold atmospheric plasma (CAP), a physical approach relying on reactive oxygen species to achieve the desirable cellular outcome, was shown to be effective in enhancing virus propagation, where bovine rhinotrachieitis virus and Madin-Darby Bovine Kidney cells were used as the modeling virus and cell line, respectively. CAP was shown to create synergies with virus infection in arresting host cells at the G2/M stage, decreasing cell membrane potential, increasing intracellular calcium level, and inducing selective autophagy. In addition, CAP was demonstrated to suppress virus-triggered immunogenic signaling as evaluated by IRF7 expression. We presented evidences on CAP-triggered maximization of host resources toward virus multiplication that is advantageous for viral vaccine production, and opened a novel regime for applying CAP in the sector of medical care and health.http://dx.doi.org/10.1080/21505594.2021.1883933cold atmospheric plasmaibrvmdbkhost-virus interaction |
| spellingShingle | Yujie Miao Peiyu Han Dong Hua Renwu Zhou Zhengbing Guan Qing Lv Xiaofeng Dai Cold atmospheric plasma increases IBRV titer in MDBK cells by orchestrating the host cell network Virulence cold atmospheric plasma ibrv mdbk host-virus interaction |
| title | Cold atmospheric plasma increases IBRV titer in MDBK cells by orchestrating the host cell network |
| title_full | Cold atmospheric plasma increases IBRV titer in MDBK cells by orchestrating the host cell network |
| title_fullStr | Cold atmospheric plasma increases IBRV titer in MDBK cells by orchestrating the host cell network |
| title_full_unstemmed | Cold atmospheric plasma increases IBRV titer in MDBK cells by orchestrating the host cell network |
| title_short | Cold atmospheric plasma increases IBRV titer in MDBK cells by orchestrating the host cell network |
| title_sort | cold atmospheric plasma increases ibrv titer in mdbk cells by orchestrating the host cell network |
| topic | cold atmospheric plasma ibrv mdbk host-virus interaction |
| url | http://dx.doi.org/10.1080/21505594.2021.1883933 |
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