Modeling Membrane Curvature Generation due to Membrane–Protein Interactions
To alter and adjust the shape of the plasma membrane, cells harness various mechanisms of curvature generation. Many of these curvature generation mechanisms rely on the interactions between peripheral membrane proteins, integral membrane proteins, and lipids in the bilayer membrane. Mathematical an...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/8/4/120 |
| _version_ | 1819058153327689728 |
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| author | Haleh Alimohamadi Padmini Rangamani |
| author_facet | Haleh Alimohamadi Padmini Rangamani |
| author_sort | Haleh Alimohamadi |
| collection | DOAJ |
| description | To alter and adjust the shape of the plasma membrane, cells harness various mechanisms of curvature generation. Many of these curvature generation mechanisms rely on the interactions between peripheral membrane proteins, integral membrane proteins, and lipids in the bilayer membrane. Mathematical and computational modeling of membrane curvature generation has provided great insights into the physics underlying these processes. However, one of the challenges in modeling these processes is identifying the suitable constitutive relationships that describe the membrane free energy including protein distribution and curvature generation capability. Here, we review some of the commonly used continuum elastic membrane models that have been developed for this purpose and discuss their applications. Finally, we address some fundamental challenges that future theoretical methods need to overcome to push the boundaries of current model applications. |
| first_indexed | 2024-12-21T13:50:40Z |
| format | Article |
| id | doaj.art-7f9e66ae116f41298d3f83ac0f6ebf29 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-12-21T13:50:40Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-7f9e66ae116f41298d3f83ac0f6ebf292022-12-21T19:01:43ZengMDPI AGBiomolecules2218-273X2018-10-018412010.3390/biom8040120biom8040120Modeling Membrane Curvature Generation due to Membrane–Protein InteractionsHaleh Alimohamadi0Padmini Rangamani1Department of Mechanical and Aerospace Engineering, University of California, San Diego, CA 92093, USADepartment of Mechanical and Aerospace Engineering, University of California, San Diego, CA 92093, USATo alter and adjust the shape of the plasma membrane, cells harness various mechanisms of curvature generation. Many of these curvature generation mechanisms rely on the interactions between peripheral membrane proteins, integral membrane proteins, and lipids in the bilayer membrane. Mathematical and computational modeling of membrane curvature generation has provided great insights into the physics underlying these processes. However, one of the challenges in modeling these processes is identifying the suitable constitutive relationships that describe the membrane free energy including protein distribution and curvature generation capability. Here, we review some of the commonly used continuum elastic membrane models that have been developed for this purpose and discuss their applications. Finally, we address some fundamental challenges that future theoretical methods need to overcome to push the boundaries of current model applications.https://www.mdpi.com/2218-273X/8/4/120plasma membranespontaneous curvatureHelfrich energyarea difference elastic modelprotein crowdingdeviatoric curvaturehydrophobic mismatch |
| spellingShingle | Haleh Alimohamadi Padmini Rangamani Modeling Membrane Curvature Generation due to Membrane–Protein Interactions Biomolecules plasma membrane spontaneous curvature Helfrich energy area difference elastic model protein crowding deviatoric curvature hydrophobic mismatch |
| title | Modeling Membrane Curvature Generation due to Membrane–Protein Interactions |
| title_full | Modeling Membrane Curvature Generation due to Membrane–Protein Interactions |
| title_fullStr | Modeling Membrane Curvature Generation due to Membrane–Protein Interactions |
| title_full_unstemmed | Modeling Membrane Curvature Generation due to Membrane–Protein Interactions |
| title_short | Modeling Membrane Curvature Generation due to Membrane–Protein Interactions |
| title_sort | modeling membrane curvature generation due to membrane protein interactions |
| topic | plasma membrane spontaneous curvature Helfrich energy area difference elastic model protein crowding deviatoric curvature hydrophobic mismatch |
| url | https://www.mdpi.com/2218-273X/8/4/120 |
| work_keys_str_mv | AT halehalimohamadi modelingmembranecurvaturegenerationduetomembraneproteininteractions AT padminirangamani modelingmembranecurvaturegenerationduetomembraneproteininteractions |