Aminooxy acetic acid suppresses Th17-mediated psoriasis-like skin inflammation by inhibiting serine metabolism

Aminooxy acetic acid suppresses Th17-mediated psoriasis-like skin inflammation by inhibiting serine metabolism

Background: Psoriasis is a common chronic inflammatory skin disease characterized by an external red rash that is caused by abnormal proliferation and differentiation of keratinocytes and immune T cells. This study aimed to elucidate the role of aminooxy acetic acid (AOA) in alleviating psoriasis fr...

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Bibliographic Details
Main Authors: Jong Yeong Lee, Ji-Hyun Lee, Hyo Jung Lim, Eonho Kim, Dae-Ki Kim, Jin Kyeong Choi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Pharmacology
Subjects:
psoriasis
aminooxy acetic acid
serine metabolism
Th17
Treg
mTOR
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1215861/full

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