Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases
Treatment with sotorasib has shown intracranial complete responses and continued intracranial stabilization in KRAS G12C-mutated non-small-cell lung carcinoma (NSCLC) patients with previously treated, stable brain metastases in a post hoc analysis of the ongoing CodeBreaK 100 trial. We present the c...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2022-08-01
|
| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/525341 |
| _version_ | 1818050106674380800 |
|---|---|
| author | Kira-Lee Koster Christina Appenzeller Arno Lauber Martin Früh Sabine Schmid |
| author_facet | Kira-Lee Koster Christina Appenzeller Arno Lauber Martin Früh Sabine Schmid |
| author_sort | Kira-Lee Koster |
| collection | DOAJ |
| description | Treatment with sotorasib has shown intracranial complete responses and continued intracranial stabilization in KRAS G12C-mutated non-small-cell lung carcinoma (NSCLC) patients with previously treated, stable brain metastases in a post hoc analysis of the ongoing CodeBreaK 100 trial. We present the case of a patient with KRAS G12C-mutant adenocarcinoma of the lung with active untreated brain metastases with a nearly complete intracranial response only 6 weeks after start of sotorasib illustrating the benefit of sotorasib in patients with active, previously untreated brain metastases in KRAS G12C-mutated NSCLC. |
| first_indexed | 2024-12-10T10:48:12Z |
| format | Article |
| id | doaj.art-7f9f665b6c8f46ef8985031e19131fb5 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-12-10T10:48:12Z |
| publishDate | 2022-08-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-7f9f665b6c8f46ef8985031e19131fb52022-12-22T01:52:05ZengKarger PublishersCase Reports in Oncology1662-65752022-08-0115272072510.1159/000525341525341Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain MetastasesKira-Lee Koster0Christina Appenzeller1https://orcid.org/0000-0001-8710-255XArno Lauber2Martin Früh3Sabine Schmid4Department of Medical Oncology and Hematology, Cantonal Hospital St. Gallen, St. Gallen, SwitzerlandDepartment of Medical Oncology and Hematology, Cantonal Hospital St. Gallen, St. Gallen, SwitzerlandDepartment of Radiology, Cantonal Hospital St. Gallen, St. Gallen, SwitzerlandDepartment of Medical Oncology and Hematology, Cantonal Hospital St. Gallen, St. Gallen, SwitzerlandDepartment of Medical Oncology and Hematology, Cantonal Hospital St. Gallen, St. Gallen, SwitzerlandTreatment with sotorasib has shown intracranial complete responses and continued intracranial stabilization in KRAS G12C-mutated non-small-cell lung carcinoma (NSCLC) patients with previously treated, stable brain metastases in a post hoc analysis of the ongoing CodeBreaK 100 trial. We present the case of a patient with KRAS G12C-mutant adenocarcinoma of the lung with active untreated brain metastases with a nearly complete intracranial response only 6 weeks after start of sotorasib illustrating the benefit of sotorasib in patients with active, previously untreated brain metastases in KRAS G12C-mutated NSCLC.https://www.karger.com/Article/FullText/525341kras-mutated nsclckras inhibitionnsclc with active brain metastases |
| spellingShingle | Kira-Lee Koster Christina Appenzeller Arno Lauber Martin Früh Sabine Schmid Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases Case Reports in Oncology kras-mutated nsclc kras inhibition nsclc with active brain metastases |
| title | Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases |
| title_full | Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases |
| title_fullStr | Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases |
| title_full_unstemmed | Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases |
| title_short | Sotorasib Shows Intracranial Activity in Patients with KRAS G12C-Mutated Adenocarcinoma of the Lung and Untreated Active Brain Metastases |
| title_sort | sotorasib shows intracranial activity in patients with kras g12c mutated adenocarcinoma of the lung and untreated active brain metastases |
| topic | kras-mutated nsclc kras inhibition nsclc with active brain metastases |
| url | https://www.karger.com/Article/FullText/525341 |
| work_keys_str_mv | AT kiraleekoster sotorasibshowsintracranialactivityinpatientswithkrasg12cmutatedadenocarcinomaofthelunganduntreatedactivebrainmetastases AT christinaappenzeller sotorasibshowsintracranialactivityinpatientswithkrasg12cmutatedadenocarcinomaofthelunganduntreatedactivebrainmetastases AT arnolauber sotorasibshowsintracranialactivityinpatientswithkrasg12cmutatedadenocarcinomaofthelunganduntreatedactivebrainmetastases AT martinfruh sotorasibshowsintracranialactivityinpatientswithkrasg12cmutatedadenocarcinomaofthelunganduntreatedactivebrainmetastases AT sabineschmid sotorasibshowsintracranialactivityinpatientswithkrasg12cmutatedadenocarcinomaofthelunganduntreatedactivebrainmetastases |