A case report of melanotic neuroectodermal tumor of infancy complicated with congenital heart disease and hypothyroidism
To the best of our knowledge, thus far there are no reported cases of melanotic neuroectodermal tumor of infancy (MNTI) with multiple complications. In this case report, we describe the clinical phenotype of MNTI in a 9-month-old female infant associated with tetralogy of Fallot (TOF), a congenital...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.924538/full |
| _version_ | 1811232789954035712 |
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| author | Hua-Chu Zuo Jin-Yue Huang Xiao-Li Hu Lin-Sheng Zhao |
| author_facet | Hua-Chu Zuo Jin-Yue Huang Xiao-Li Hu Lin-Sheng Zhao |
| author_sort | Hua-Chu Zuo |
| collection | DOAJ |
| description | To the best of our knowledge, thus far there are no reported cases of melanotic neuroectodermal tumor of infancy (MNTI) with multiple complications. In this case report, we describe the clinical phenotype of MNTI in a 9-month-old female infant associated with tetralogy of Fallot (TOF), a congenital heart defect, and congenital hypothyroidism (CH). Our study showed that the growth of MNTI was delayed by a lower dosage of levothyroxine (L-T4) that was prescribed to treat CH because of the presence of TOF, a severe congenital heart disease. However, the standardized dosage of L-T4 improved thyroid function but stimulated the rapid growth of MNTI. Our report demonstrated that treatment with L-T4 affects the progression of MNTI. Our findings demonstrated the role of thyroid hormone in MNTI growth and progression. Furthermore, our study suggested that the treatment of co-morbidities in children with MNTI requires careful consideration of their effects on the growth and progression of MNTI. |
| first_indexed | 2024-04-12T11:09:13Z |
| format | Article |
| id | doaj.art-7fa1ae6cda0646bea9d82ce2d6fc7b46 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T11:09:13Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-7fa1ae6cda0646bea9d82ce2d6fc7b462022-12-22T03:35:39ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-11-01910.3389/fcvm.2022.924538924538A case report of melanotic neuroectodermal tumor of infancy complicated with congenital heart disease and hypothyroidismHua-Chu Zuo0Jin-Yue Huang1Xiao-Li Hu2Lin-Sheng Zhao3Department of Pathology, Tianjin Children’s Hospital (Tianjin University Children’s Hospital), Tianjin, ChinaInstitute of Pediatrics, Tianjin Children’s Hospital (Tianjin University Children’s Hospital), Tianjin, ChinaDepartment of Pathology, Tianjin Children’s Hospital (Tianjin University Children’s Hospital), Tianjin, ChinaDepartment of Pathology, Tianjin Children’s Hospital (Tianjin University Children’s Hospital), Tianjin, ChinaTo the best of our knowledge, thus far there are no reported cases of melanotic neuroectodermal tumor of infancy (MNTI) with multiple complications. In this case report, we describe the clinical phenotype of MNTI in a 9-month-old female infant associated with tetralogy of Fallot (TOF), a congenital heart defect, and congenital hypothyroidism (CH). Our study showed that the growth of MNTI was delayed by a lower dosage of levothyroxine (L-T4) that was prescribed to treat CH because of the presence of TOF, a severe congenital heart disease. However, the standardized dosage of L-T4 improved thyroid function but stimulated the rapid growth of MNTI. Our report demonstrated that treatment with L-T4 affects the progression of MNTI. Our findings demonstrated the role of thyroid hormone in MNTI growth and progression. Furthermore, our study suggested that the treatment of co-morbidities in children with MNTI requires careful consideration of their effects on the growth and progression of MNTI.https://www.frontiersin.org/articles/10.3389/fcvm.2022.924538/fullmelanotic neuroectodermal tumor of infancycongenital heart diseasehypothyroidismcase reportfrequently encountered disease |
| spellingShingle | Hua-Chu Zuo Jin-Yue Huang Xiao-Li Hu Lin-Sheng Zhao A case report of melanotic neuroectodermal tumor of infancy complicated with congenital heart disease and hypothyroidism Frontiers in Cardiovascular Medicine melanotic neuroectodermal tumor of infancy congenital heart disease hypothyroidism case report frequently encountered disease |
| title | A case report of melanotic neuroectodermal tumor of infancy complicated with congenital heart disease and hypothyroidism |
| title_full | A case report of melanotic neuroectodermal tumor of infancy complicated with congenital heart disease and hypothyroidism |
| title_fullStr | A case report of melanotic neuroectodermal tumor of infancy complicated with congenital heart disease and hypothyroidism |
| title_full_unstemmed | A case report of melanotic neuroectodermal tumor of infancy complicated with congenital heart disease and hypothyroidism |
| title_short | A case report of melanotic neuroectodermal tumor of infancy complicated with congenital heart disease and hypothyroidism |
| title_sort | case report of melanotic neuroectodermal tumor of infancy complicated with congenital heart disease and hypothyroidism |
| topic | melanotic neuroectodermal tumor of infancy congenital heart disease hypothyroidism case report frequently encountered disease |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.924538/full |
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