Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation

Zebrafish mutants reveal unexpected role of Lrp5 in osteoclast regulation

Low-density Lipoprotein Receptor-related Protein 5 (LRP5) functions as a co-receptor for Wnt ligands, controlling expression of genes involved in osteogenesis. In humans, loss-of-function mutations in LRP5 cause Osteoporosis-Pseudoglioma syndrome, a low bone mass disorder, while gain-of-function mis...

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Bibliographic Details
Main Authors: Iryna Khrystoforova, Chen Shochat-Carvalho, Ram Harari, Katrin Henke, Katherine Woronowicz, Matthew P. Harris, David Karasik
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Endocrinology
Subjects:
lrp5
zebrafish
bone
osteoclast
osteoporosis
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.985304/full

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