Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice
Obesity and nonalcoholic fatty liver disease (NAFLD) are highly prevalent and cause numerous metabolic diseases. However, drugs for the prevention and treatment of obesity and NAFLD remain unavailable. In this study, we investigated the effects of mogrosides (luo han guo, LH) in Siraitia grosvenorii...
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MDPI AG
2018-07-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/23/8/1894 |
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| author | Xiaobing Zhang Yunfei Song Yipei Ding Wei Wang Ling Liao Jin Zhong Pengbo Sun Fan Lei Yaou Zhang Weidong Xie |
| author_facet | Xiaobing Zhang Yunfei Song Yipei Ding Wei Wang Ling Liao Jin Zhong Pengbo Sun Fan Lei Yaou Zhang Weidong Xie |
| author_sort | Xiaobing Zhang |
| collection | DOAJ |
| description | Obesity and nonalcoholic fatty liver disease (NAFLD) are highly prevalent and cause numerous metabolic diseases. However, drugs for the prevention and treatment of obesity and NAFLD remain unavailable. In this study, we investigated the effects of mogrosides (luo han guo, LH) in Siraitia grosvenorii saponins on high-fat-diet-induced obesity and NAFLD in mice. We found that compared with the negative control, LH reduced body and liver weight. LH also decreased fat accumulation and increased AMP-activated protein kinase (AMPK) phosphorylation (pAMPK) levels in mouse livers. We also found that high-purity mogroside V upregulated pAMPK expression in HepG2 cells. In addition, high-purity mogroside V inhibited reactive oxygen species production and upregulated sequestosome-1 (SQSTM1, p62) expression in THP-1 cells. These results suggest that LH may affect obesity and NAFLD by enhancing fat metabolism and antioxidative defenses. Mogroside V may be a main component of LH. However, the exact molecular mechanisms and active components responsible for the inhibitory effects of LH on obesity and NAFLD require further investigation. |
| first_indexed | 2024-12-11T01:25:29Z |
| format | Article |
| id | doaj.art-7fa5a61ff0dd45e3a64ae8a78774a1a9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T01:25:29Z |
| publishDate | 2018-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-7fa5a61ff0dd45e3a64ae8a78774a1a92022-12-22T01:25:31ZengMDPI AGMolecules1420-30492018-07-01238189410.3390/molecules23081894molecules23081894Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in MiceXiaobing Zhang0Yunfei Song1Yipei Ding2Wei Wang3Ling Liao4Jin Zhong5Pengbo Sun6Fan Lei7Yaou Zhang8Weidong Xie9Department of Chemistry, Tsinghua University, Beijing 100084, ChinaGuilin Layn Natural Ingredients Corp., Guilin 541100, ChinaDepartment of Chemistry, Tsinghua University, Beijing 100084, ChinaOpen FIESTA Center, Tsinghua University, Shenzhen 518055, ChinaOpen FIESTA Center, Tsinghua University, Shenzhen 518055, ChinaOpen FIESTA Center, Tsinghua University, Shenzhen 518055, ChinaOpen FIESTA Center, Tsinghua University, Shenzhen 518055, ChinaLaboratory of Pharmaceutical Science, School of Life Science, School of Medicine, Tsinghua University, Beijing 100084, ChinaState Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen, ChinaState Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen, ChinaObesity and nonalcoholic fatty liver disease (NAFLD) are highly prevalent and cause numerous metabolic diseases. However, drugs for the prevention and treatment of obesity and NAFLD remain unavailable. In this study, we investigated the effects of mogrosides (luo han guo, LH) in Siraitia grosvenorii saponins on high-fat-diet-induced obesity and NAFLD in mice. We found that compared with the negative control, LH reduced body and liver weight. LH also decreased fat accumulation and increased AMP-activated protein kinase (AMPK) phosphorylation (pAMPK) levels in mouse livers. We also found that high-purity mogroside V upregulated pAMPK expression in HepG2 cells. In addition, high-purity mogroside V inhibited reactive oxygen species production and upregulated sequestosome-1 (SQSTM1, p62) expression in THP-1 cells. These results suggest that LH may affect obesity and NAFLD by enhancing fat metabolism and antioxidative defenses. Mogroside V may be a main component of LH. However, the exact molecular mechanisms and active components responsible for the inhibitory effects of LH on obesity and NAFLD require further investigation.http://www.mdpi.com/1420-3049/23/8/1894Siraitia grosvenoriimogrosidesobesitynonalcoholic fatty liver diseaseAMPKp62 |
| spellingShingle | Xiaobing Zhang Yunfei Song Yipei Ding Wei Wang Ling Liao Jin Zhong Pengbo Sun Fan Lei Yaou Zhang Weidong Xie Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice Molecules Siraitia grosvenorii mogrosides obesity nonalcoholic fatty liver disease AMPK p62 |
| title | Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice |
| title_full | Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice |
| title_fullStr | Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice |
| title_full_unstemmed | Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice |
| title_short | Effects of Mogrosides on High-Fat-Diet-Induced Obesity and Nonalcoholic Fatty Liver Disease in Mice |
| title_sort | effects of mogrosides on high fat diet induced obesity and nonalcoholic fatty liver disease in mice |
| topic | Siraitia grosvenorii mogrosides obesity nonalcoholic fatty liver disease AMPK p62 |
| url | http://www.mdpi.com/1420-3049/23/8/1894 |
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