Hepatitis B Co-Infection Has Limited Impact on Liver Stiffness Regression in Chronic Hepatitis C Patients Treated with Direct-Acting Antivirals
Introduction: High sustained virological response (SVR) rate (>95%) and liver stiffness regression can be achieved with direct acting antivirals treatment (DAA) in patients with chronic hepatitis C virus (CHC) infection. Reactivation of hepatitis B virus (HBV) was reported during DAA treatment in...
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MDPI AG
2022-04-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/4/786 |
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| author | Cheng-Er Hsu Yen-Chun Liu Ya-Ting Cheng Wen-Juei Jeng Rong-Nan Chien Chun-Yen Lin Dar-In Tai I-Shyan Sheen |
| author_facet | Cheng-Er Hsu Yen-Chun Liu Ya-Ting Cheng Wen-Juei Jeng Rong-Nan Chien Chun-Yen Lin Dar-In Tai I-Shyan Sheen |
| author_sort | Cheng-Er Hsu |
| collection | DOAJ |
| description | Introduction: High sustained virological response (SVR) rate (>95%) and liver stiffness regression can be achieved with direct acting antivirals treatment (DAA) in patients with chronic hepatitis C virus (CHC) infection. Reactivation of hepatitis B virus (HBV) was reported during DAA treatment in patients co-infected with HBV, although its impact on liver stiffness remains unknown. This study aims to investigate whether the liver stiffness (LSM) regression is different between HBV/HCV co-infected and mono-HCV-infected patients. Materials and Methods: CHC patients with/without HBV co-infection who received DAA treatment and achieved SVR12 between March 2015 and December 2019 in Chang Gung Memorial Hospital, Linkou branch were prospectively enrolled. LSM was assessed by transient elastography (TE, Fibroscan) at baseline and after SVR. Propensity score matching (PSM) at 3:1 ratio, adjusted for age, gender, pre-DAA alanine aminotransferase (ALT), platelet count, and LSM, between CHC with and without HBV co-infection, was performed before further analysis. Results: Among 906 CHC patients enrolled, 52 (5.7%) patients had HBV/HCV co-infection. Patients with HBV/HCV co-infection were of younger age (61.8 vs. 63.2, <i>p</i> = 0.31), with a higher proportion of males (53.8% vs. 38.9%, <i>p</i> = 0.03), and lower pretreatment LSM level (8.15 vs. 10.2 kPa, <i>p</i> = 0.09), while other features were comparable. After PSM, patients with HBV/HCV co-infection had insignificantly lower LSM regression compared to mono-HCV-infected patients (−0.85 kPa vs. −1.65 kPa, <i>p</i> = 0.250). Conclusions: The co-infection of HBV among CHC patients has limited impact on liver stiffness regression after successful DAA treatment. |
| first_indexed | 2024-03-09T04:07:49Z |
| format | Article |
| id | doaj.art-7fa8a4c50cf44dddb6c21cecd5a993e5 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T04:07:49Z |
| publishDate | 2022-04-01 |
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| series | Viruses |
| spelling | doaj.art-7fa8a4c50cf44dddb6c21cecd5a993e52023-12-03T14:04:23ZengMDPI AGViruses1999-49152022-04-0114478610.3390/v14040786Hepatitis B Co-Infection Has Limited Impact on Liver Stiffness Regression in Chronic Hepatitis C Patients Treated with Direct-Acting AntiviralsCheng-Er Hsu0Yen-Chun Liu1Ya-Ting Cheng2Wen-Juei Jeng3Rong-Nan Chien4Chun-Yen Lin5Dar-In Tai6I-Shyan Sheen7Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan 333, TaiwanDepartment of Gastroenterology and Hepatology, Chang Gung Memorial Hospital Linkou Medical Center, Taoyuan 333, TaiwanIntroduction: High sustained virological response (SVR) rate (>95%) and liver stiffness regression can be achieved with direct acting antivirals treatment (DAA) in patients with chronic hepatitis C virus (CHC) infection. Reactivation of hepatitis B virus (HBV) was reported during DAA treatment in patients co-infected with HBV, although its impact on liver stiffness remains unknown. This study aims to investigate whether the liver stiffness (LSM) regression is different between HBV/HCV co-infected and mono-HCV-infected patients. Materials and Methods: CHC patients with/without HBV co-infection who received DAA treatment and achieved SVR12 between March 2015 and December 2019 in Chang Gung Memorial Hospital, Linkou branch were prospectively enrolled. LSM was assessed by transient elastography (TE, Fibroscan) at baseline and after SVR. Propensity score matching (PSM) at 3:1 ratio, adjusted for age, gender, pre-DAA alanine aminotransferase (ALT), platelet count, and LSM, between CHC with and without HBV co-infection, was performed before further analysis. Results: Among 906 CHC patients enrolled, 52 (5.7%) patients had HBV/HCV co-infection. Patients with HBV/HCV co-infection were of younger age (61.8 vs. 63.2, <i>p</i> = 0.31), with a higher proportion of males (53.8% vs. 38.9%, <i>p</i> = 0.03), and lower pretreatment LSM level (8.15 vs. 10.2 kPa, <i>p</i> = 0.09), while other features were comparable. After PSM, patients with HBV/HCV co-infection had insignificantly lower LSM regression compared to mono-HCV-infected patients (−0.85 kPa vs. −1.65 kPa, <i>p</i> = 0.250). Conclusions: The co-infection of HBV among CHC patients has limited impact on liver stiffness regression after successful DAA treatment.https://www.mdpi.com/1999-4915/14/4/786HBV reactivationhepatocellular carcinomahepatic decompensation |
| spellingShingle | Cheng-Er Hsu Yen-Chun Liu Ya-Ting Cheng Wen-Juei Jeng Rong-Nan Chien Chun-Yen Lin Dar-In Tai I-Shyan Sheen Hepatitis B Co-Infection Has Limited Impact on Liver Stiffness Regression in Chronic Hepatitis C Patients Treated with Direct-Acting Antivirals Viruses HBV reactivation hepatocellular carcinoma hepatic decompensation |
| title | Hepatitis B Co-Infection Has Limited Impact on Liver Stiffness Regression in Chronic Hepatitis C Patients Treated with Direct-Acting Antivirals |
| title_full | Hepatitis B Co-Infection Has Limited Impact on Liver Stiffness Regression in Chronic Hepatitis C Patients Treated with Direct-Acting Antivirals |
| title_fullStr | Hepatitis B Co-Infection Has Limited Impact on Liver Stiffness Regression in Chronic Hepatitis C Patients Treated with Direct-Acting Antivirals |
| title_full_unstemmed | Hepatitis B Co-Infection Has Limited Impact on Liver Stiffness Regression in Chronic Hepatitis C Patients Treated with Direct-Acting Antivirals |
| title_short | Hepatitis B Co-Infection Has Limited Impact on Liver Stiffness Regression in Chronic Hepatitis C Patients Treated with Direct-Acting Antivirals |
| title_sort | hepatitis b co infection has limited impact on liver stiffness regression in chronic hepatitis c patients treated with direct acting antivirals |
| topic | HBV reactivation hepatocellular carcinoma hepatic decompensation |
| url | https://www.mdpi.com/1999-4915/14/4/786 |
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