Enhanced Anti-Glioma Efficacy by Borneol Combined With CGKRK-Modified Paclitaxel Self-Assembled Redox-Sensitive Nanoparticles

Enhanced Anti-Glioma Efficacy by Borneol Combined With CGKRK-Modified Paclitaxel Self-Assembled Redox-Sensitive Nanoparticles

The serious therapeutic obstacles to glioma treatment include poor penetration across the blood-brain barrier (BBB) and low accumulation of therapeutic drugs at tumor sites. In this study, borneol combined with CGKRK peptide (a ligand of the heparan sulfate which overexpress on the glioma cells) mod...

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Bibliographic Details
Main Authors: Lingyan Lv, Xinrui Li, Wei Qian, Shennan Li, Yan Jiang, Yaokun Xiong, Jianpei Xu, Wei Lv, Xiaoyan Liu, Yun Chen, Yulin Tang, Hongliang Xin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pharmacology
Subjects:
borneol
blood-brain barrier penetration
paclitaxel
redox-responsive nanoparticles
CGKRK peptide
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00558/full

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