Gut Microbiota and Sex Hormones: Crosstalking Players in Cardiometabolic and Cardiovascular Disease
The available evidence indicates a close connection between gut microbiota (GM) disturbance and increased risk of cardiometabolic (CM) disorders and cardiovascular (CV) disease. One major objective of this narrative review is to discuss the key contribution of dietary regimen in determining the GM b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/13/7154 |
| _version_ | 1797479727957540864 |
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| author | Silvia Maffei Francesca Forini Paola Canale Giuseppina Nicolini Letizia Guiducci |
| author_facet | Silvia Maffei Francesca Forini Paola Canale Giuseppina Nicolini Letizia Guiducci |
| author_sort | Silvia Maffei |
| collection | DOAJ |
| description | The available evidence indicates a close connection between gut microbiota (GM) disturbance and increased risk of cardiometabolic (CM) disorders and cardiovascular (CV) disease. One major objective of this narrative review is to discuss the key contribution of dietary regimen in determining the GM biodiversity and the implications of GM dysbiosis for the overall health of the CV system. In particular, emerging molecular pathways are presented, linking microbiota-derived signals to the local activation of the immune system as the driver of a systemic proinflammatory state and permissive condition for the onset and progression of CM and CV disease. We further outline how the cross-talk between sex hormones and GM impacts disease susceptibility, thereby offering a mechanistic insight into sexual dimorphism observed in CVD. A better understanding of these relationships could help unravel novel disease targets and pave the way to the development of innovative, low-risk therapeutic strategies based on diet interventions, GM manipulation, and sex hormone analogues. |
| first_indexed | 2024-03-09T21:49:57Z |
| format | Article |
| id | doaj.art-7fa9e425700a4c05abf61f308ec277f7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:49:57Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-7fa9e425700a4c05abf61f308ec277f72023-11-23T20:08:59ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012313715410.3390/ijms23137154Gut Microbiota and Sex Hormones: Crosstalking Players in Cardiometabolic and Cardiovascular DiseaseSilvia Maffei0Francesca Forini1Paola Canale2Giuseppina Nicolini3Letizia Guiducci4Department of Gynecological and Cardiovascular Endocrinology, CNR-Tuscany Region, G. Monasterio Foundation, Via G. Moruzzi 1, 56124 Pisa, ItalyCNR Institute of Clinical Physiology, Via G Moruzzi 1, 56124 Pisa, ItalyCNR Institute of Clinical Physiology, Via G Moruzzi 1, 56124 Pisa, ItalyCNR Institute of Clinical Physiology, Via G Moruzzi 1, 56124 Pisa, ItalyCNR Institute of Clinical Physiology, Via G Moruzzi 1, 56124 Pisa, ItalyThe available evidence indicates a close connection between gut microbiota (GM) disturbance and increased risk of cardiometabolic (CM) disorders and cardiovascular (CV) disease. One major objective of this narrative review is to discuss the key contribution of dietary regimen in determining the GM biodiversity and the implications of GM dysbiosis for the overall health of the CV system. In particular, emerging molecular pathways are presented, linking microbiota-derived signals to the local activation of the immune system as the driver of a systemic proinflammatory state and permissive condition for the onset and progression of CM and CV disease. We further outline how the cross-talk between sex hormones and GM impacts disease susceptibility, thereby offering a mechanistic insight into sexual dimorphism observed in CVD. A better understanding of these relationships could help unravel novel disease targets and pave the way to the development of innovative, low-risk therapeutic strategies based on diet interventions, GM manipulation, and sex hormone analogues.https://www.mdpi.com/1422-0067/23/13/7154gut microbiotadietsex hormonecardiometabolic diseasemolecular mechanisms |
| spellingShingle | Silvia Maffei Francesca Forini Paola Canale Giuseppina Nicolini Letizia Guiducci Gut Microbiota and Sex Hormones: Crosstalking Players in Cardiometabolic and Cardiovascular Disease International Journal of Molecular Sciences gut microbiota diet sex hormone cardiometabolic disease molecular mechanisms |
| title | Gut Microbiota and Sex Hormones: Crosstalking Players in Cardiometabolic and Cardiovascular Disease |
| title_full | Gut Microbiota and Sex Hormones: Crosstalking Players in Cardiometabolic and Cardiovascular Disease |
| title_fullStr | Gut Microbiota and Sex Hormones: Crosstalking Players in Cardiometabolic and Cardiovascular Disease |
| title_full_unstemmed | Gut Microbiota and Sex Hormones: Crosstalking Players in Cardiometabolic and Cardiovascular Disease |
| title_short | Gut Microbiota and Sex Hormones: Crosstalking Players in Cardiometabolic and Cardiovascular Disease |
| title_sort | gut microbiota and sex hormones crosstalking players in cardiometabolic and cardiovascular disease |
| topic | gut microbiota diet sex hormone cardiometabolic disease molecular mechanisms |
| url | https://www.mdpi.com/1422-0067/23/13/7154 |
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