Exosome-transmitted circCABIN1 promotes temozolomide resistance in glioblastoma via sustaining ErbB downstream signaling

Exosome-transmitted circCABIN1 promotes temozolomide resistance in glioblastoma via sustaining ErbB downstream signaling

Abstract Although temozolomide (TMZ) provides significant clinical benefit for glioblastoma (GBM), responses are limited by the emergence of acquired resistance. Here, we demonstrate that exosomal circCABIN1 secreted from TMZ-resistant cells was packaged into exosomes and then disseminated TMZ resis...

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Bibliographic Details
Main Authors: Xiao Liu, Qingdong Guo, Guangxun Gao, Zhengcong Cao, Zhihao Guan, Bo Jia, Weizhong Wang, Kuo Zhang, Wangqian Zhang, Shuning Wang, Weina Li, Qiang Hao, Yingqi Zhang, Meng Li, Wei Zhang, Jintao Gu
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Nanobiotechnology
Subjects:
Glioblastoma
Temozolomide resistance
Exosome
circCABIN1
Stemness
Online Access:https://doi.org/10.1186/s12951-023-01801-w

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