Psoriasis Therapy and Skin Cancer: A Review
Introduction: psoriasis is a chronic immune-mediated disease that is associated with several comorbidities, including an increased risk of malignancies, particularly skin cancer. A large number of studies have investigated whether psoriasis itself, psoriasis-associated comorbidities, or psoriasis tr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/10/1109 |
| _version_ | 1827679265764671488 |
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| author | Beatriz Butrón-Bris Esteban Daudén Pedro Rodríguez-Jiménez |
| author_facet | Beatriz Butrón-Bris Esteban Daudén Pedro Rodríguez-Jiménez |
| author_sort | Beatriz Butrón-Bris |
| collection | DOAJ |
| description | Introduction: psoriasis is a chronic immune-mediated disease that is associated with several comorbidities, including an increased risk of malignancies, particularly skin cancer. A large number of studies have investigated whether psoriasis itself, psoriasis-associated comorbidities, or psoriasis treatment could lead to an increased risk of neoplasms. Methods: we reviewed the literature using the most important databases (PubMed, MEDLINE, ETHERIA). All articles pertaining to skin cancer associated with psoriasis disease and psoriasis therapy were included. In this review, we also discuss some of the potential underlying mechanisms for these associations, particularly regarding the multiple psoriasis therapies currently available, and their possible implications in higher incidences of skin cancer in these patients. Conclusion: evidence suggests that these patients might have a higher risk of cutaneous malignancies, especially for NMSC, compared with psoriasis-free patients. The reasons for this increased risk remain to be determined. However, high dose PUVA therapy, the immunosuppressive treatments used, and the comorbidities and habits frequently described in these patients seem to play a role in the pathogenesis of these tumors. Because of these facts, periodic screening for skin cancer is recommended in this population. |
| first_indexed | 2024-03-10T06:26:59Z |
| format | Article |
| id | doaj.art-7fac45c8a506446b8ca568a772178c07 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T06:26:59Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-7fac45c8a506446b8ca568a772178c072023-11-22T18:53:44ZengMDPI AGLife2075-17292021-10-011110110910.3390/life11101109Psoriasis Therapy and Skin Cancer: A ReviewBeatriz Butrón-Bris0Esteban Daudén1Pedro Rodríguez-Jiménez2Dermatology Deparment, Hospital Universitario de la Princesa, 28007 Madrid, SpainDermatology Deparment, Hospital Universitario de la Princesa, 28007 Madrid, SpainDermatology Deparment, Hospital Universitario de la Princesa, 28007 Madrid, SpainIntroduction: psoriasis is a chronic immune-mediated disease that is associated with several comorbidities, including an increased risk of malignancies, particularly skin cancer. A large number of studies have investigated whether psoriasis itself, psoriasis-associated comorbidities, or psoriasis treatment could lead to an increased risk of neoplasms. Methods: we reviewed the literature using the most important databases (PubMed, MEDLINE, ETHERIA). All articles pertaining to skin cancer associated with psoriasis disease and psoriasis therapy were included. In this review, we also discuss some of the potential underlying mechanisms for these associations, particularly regarding the multiple psoriasis therapies currently available, and their possible implications in higher incidences of skin cancer in these patients. Conclusion: evidence suggests that these patients might have a higher risk of cutaneous malignancies, especially for NMSC, compared with psoriasis-free patients. The reasons for this increased risk remain to be determined. However, high dose PUVA therapy, the immunosuppressive treatments used, and the comorbidities and habits frequently described in these patients seem to play a role in the pathogenesis of these tumors. Because of these facts, periodic screening for skin cancer is recommended in this population.https://www.mdpi.com/2075-1729/11/10/1109psoriasisskin cancernon-melanoma skin cancermelanomaphototherapytreatment |
| spellingShingle | Beatriz Butrón-Bris Esteban Daudén Pedro Rodríguez-Jiménez Psoriasis Therapy and Skin Cancer: A Review Life psoriasis skin cancer non-melanoma skin cancer melanoma phototherapy treatment |
| title | Psoriasis Therapy and Skin Cancer: A Review |
| title_full | Psoriasis Therapy and Skin Cancer: A Review |
| title_fullStr | Psoriasis Therapy and Skin Cancer: A Review |
| title_full_unstemmed | Psoriasis Therapy and Skin Cancer: A Review |
| title_short | Psoriasis Therapy and Skin Cancer: A Review |
| title_sort | psoriasis therapy and skin cancer a review |
| topic | psoriasis skin cancer non-melanoma skin cancer melanoma phototherapy treatment |
| url | https://www.mdpi.com/2075-1729/11/10/1109 |
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