Advance in oral delivery of living material
Nowadays, living therapeutics is a promising candidate among various therapies, and oral administration of living therapeutics characterized by universality and safety avail to make the transition from bench to bedside. However, precise delivery and continuous maintenance of cell viability and activ...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2023-09-01
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| Series: | Biomedical Technology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949723X22000198 |
| _version_ | 1797736824883380224 |
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| author | Hua Liu Yanmiao Fan Jie Zhong Michael Malkoch Zhengwei Cai Zhengting Wang |
| author_facet | Hua Liu Yanmiao Fan Jie Zhong Michael Malkoch Zhengwei Cai Zhengting Wang |
| author_sort | Hua Liu |
| collection | DOAJ |
| description | Nowadays, living therapeutics is a promising candidate among various therapies, and oral administration of living therapeutics characterized by universality and safety avail to make the transition from bench to bedside. However, precise delivery and continuous maintenance of cell viability and activity to acquire stable and ideal therapeutic efficacy remain challenging. Living material is the smart integration of the flexibly programmable functionality of biomaterial and the autonomous environmental responsiveness of living elements, heralding a new era of biotherapeutics in addressing human health concerns. Here, our review aims at presenting an overview of the status of the oral delivery of living material from a biological, technical, and practical perspective, describing the clinical significance and potential, the current technological development and dilemma, as well as the prospect. |
| first_indexed | 2024-03-12T13:19:31Z |
| format | Article |
| id | doaj.art-7fadfe274fd04a2f9454b6a023ad001d |
| institution | Directory Open Access Journal |
| issn | 2949-723X |
| language | English |
| last_indexed | 2024-03-12T13:19:31Z |
| publishDate | 2023-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Biomedical Technology |
| spelling | doaj.art-7fadfe274fd04a2f9454b6a023ad001d2023-08-26T04:44:31ZengKeAi Communications Co., Ltd.Biomedical Technology2949-723X2023-09-0132639Advance in oral delivery of living materialHua Liu0Yanmiao Fan1Jie Zhong2Michael Malkoch3Zhengwei Cai4Zhengting Wang5Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, PR China; Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, PR ChinaSchool of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, SE-100 44 Stockholm, SwedenDepartment of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, PR ChinaSchool of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, SE-100 44 Stockholm, Sweden; Corresponding author.Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, PR China; Corresponding author.Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, PR China; Corresponding author.Nowadays, living therapeutics is a promising candidate among various therapies, and oral administration of living therapeutics characterized by universality and safety avail to make the transition from bench to bedside. However, precise delivery and continuous maintenance of cell viability and activity to acquire stable and ideal therapeutic efficacy remain challenging. Living material is the smart integration of the flexibly programmable functionality of biomaterial and the autonomous environmental responsiveness of living elements, heralding a new era of biotherapeutics in addressing human health concerns. Here, our review aims at presenting an overview of the status of the oral delivery of living material from a biological, technical, and practical perspective, describing the clinical significance and potential, the current technological development and dilemma, as well as the prospect.http://www.sciencedirect.com/science/article/pii/S2949723X22000198Living materialOral administrationGut microbiomeBiomaterial |
| spellingShingle | Hua Liu Yanmiao Fan Jie Zhong Michael Malkoch Zhengwei Cai Zhengting Wang Advance in oral delivery of living material Biomedical Technology Living material Oral administration Gut microbiome Biomaterial |
| title | Advance in oral delivery of living material |
| title_full | Advance in oral delivery of living material |
| title_fullStr | Advance in oral delivery of living material |
| title_full_unstemmed | Advance in oral delivery of living material |
| title_short | Advance in oral delivery of living material |
| title_sort | advance in oral delivery of living material |
| topic | Living material Oral administration Gut microbiome Biomaterial |
| url | http://www.sciencedirect.com/science/article/pii/S2949723X22000198 |
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