A functional near-infrared spectroscopy study on hemodynamic changes of patients with prolonged disorders of consciousness responding to different auditory stimuli
Abstract Treating prolonged disorders of consciousness (pDoC) is challenging. Thus, accurate assessment of residual consciousness in patients with pDoC is important for the management and recovery of patients. Functional near-infrared spectroscopy (fNIRS) can be used to detect brain activity through...
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| Format: | Article |
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BMC
2023-06-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-023-03292-6 |
| _version_ | 1797795651894902784 |
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| author | Haitao Lu Jin Jiang Juanning Si Yizheng Wang Fubiao Huang |
| author_facet | Haitao Lu Jin Jiang Juanning Si Yizheng Wang Fubiao Huang |
| author_sort | Haitao Lu |
| collection | DOAJ |
| description | Abstract Treating prolonged disorders of consciousness (pDoC) is challenging. Thus, accurate assessment of residual consciousness in patients with pDoC is important for the management and recovery of patients. Functional near-infrared spectroscopy (fNIRS) can be used to detect brain activity through changes of oxygenated hemoglobin/deoxygenated hemoglobin (HbO/HbR) concentrations changes and has recently gained increasing attention for its potential applications in assessing residual consciousness. However, the number of fNIRS studies assessing residual awareness in patients with pDoC is still limited. In this study, fNIRS was used to evaluate the brain function in 18 patients with pDoC, including 14 vegetative states (VS) and 4 minimally conscious states (MCS), and 15 healthy controls (HC). All participants accepted two types of external stimuli, i.e., active stimulation (motor imagery, MI) and passive stimulation (subject’s own name, SON). The results showed that the mean concentrations of HbO/HbR in the prefrontal cortex of the HC during the passive stimulation were significantly lower than those of the active stimulation, and the fitting slope was high. However, the hemodynamic responses of the patients with pDoC were opposite to those of the HC. Additionally, the mean concentrations of HbO/HbR increased as the level of consciousness decreased during passive stimulation. Our findings suggest that the residual level of consciousness in pDoC patients can be assessed by measuring brain responses to different stimulations using fNIRS. The present study further demonstrates the feasibility and reliability of fNIRS in assessing residual consciousness in patients with pDoC, providing a basis for its expanded clinical application. |
| first_indexed | 2024-03-13T03:21:14Z |
| format | Article |
| id | doaj.art-7fb077ff49bd4c0f941cdfe1d3049706 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-03-13T03:21:14Z |
| publishDate | 2023-06-01 |
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| series | BMC Neurology |
| spelling | doaj.art-7fb077ff49bd4c0f941cdfe1d30497062023-06-25T11:20:27ZengBMCBMC Neurology1471-23772023-06-0123111310.1186/s12883-023-03292-6A functional near-infrared spectroscopy study on hemodynamic changes of patients with prolonged disorders of consciousness responding to different auditory stimuliHaitao Lu0Jin Jiang1Juanning Si2Yizheng Wang3Fubiao Huang4Department of Neurorehabilitation, Beijing Bo’ai Hospital, Rehabilitation Research Center, School of Rehabilitation Medicine, Capital Medical UniversityLaboratory of Human Factors Engineering, China Astronaut Research and Training CentreSchool of Instrumentation Science and Opto-electronics Engineering, Beijing Information Science and Technology UniversityDepartment of Neurorehabilitation, Beijing Bo’ai Hospital, Rehabilitation Research Center, School of Rehabilitation Medicine, Capital Medical UniversityDepartment of Occupational Therapy, Rehabilitation Research Center, School of Rehabilitation Medicine, Beijing Bo’ai Hospital, Capital Medical UniversityAbstract Treating prolonged disorders of consciousness (pDoC) is challenging. Thus, accurate assessment of residual consciousness in patients with pDoC is important for the management and recovery of patients. Functional near-infrared spectroscopy (fNIRS) can be used to detect brain activity through changes of oxygenated hemoglobin/deoxygenated hemoglobin (HbO/HbR) concentrations changes and has recently gained increasing attention for its potential applications in assessing residual consciousness. However, the number of fNIRS studies assessing residual awareness in patients with pDoC is still limited. In this study, fNIRS was used to evaluate the brain function in 18 patients with pDoC, including 14 vegetative states (VS) and 4 minimally conscious states (MCS), and 15 healthy controls (HC). All participants accepted two types of external stimuli, i.e., active stimulation (motor imagery, MI) and passive stimulation (subject’s own name, SON). The results showed that the mean concentrations of HbO/HbR in the prefrontal cortex of the HC during the passive stimulation were significantly lower than those of the active stimulation, and the fitting slope was high. However, the hemodynamic responses of the patients with pDoC were opposite to those of the HC. Additionally, the mean concentrations of HbO/HbR increased as the level of consciousness decreased during passive stimulation. Our findings suggest that the residual level of consciousness in pDoC patients can be assessed by measuring brain responses to different stimulations using fNIRS. The present study further demonstrates the feasibility and reliability of fNIRS in assessing residual consciousness in patients with pDoC, providing a basis for its expanded clinical application.https://doi.org/10.1186/s12883-023-03292-6Prolonged disorders of consciousness (pDoC)Functional near-infrared spectroscopy (fNIRS)HbO/HbRActive stimulationPassive stimulation |
| spellingShingle | Haitao Lu Jin Jiang Juanning Si Yizheng Wang Fubiao Huang A functional near-infrared spectroscopy study on hemodynamic changes of patients with prolonged disorders of consciousness responding to different auditory stimuli BMC Neurology Prolonged disorders of consciousness (pDoC) Functional near-infrared spectroscopy (fNIRS) HbO/HbR Active stimulation Passive stimulation |
| title | A functional near-infrared spectroscopy study on hemodynamic changes of patients with prolonged disorders of consciousness responding to different auditory stimuli |
| title_full | A functional near-infrared spectroscopy study on hemodynamic changes of patients with prolonged disorders of consciousness responding to different auditory stimuli |
| title_fullStr | A functional near-infrared spectroscopy study on hemodynamic changes of patients with prolonged disorders of consciousness responding to different auditory stimuli |
| title_full_unstemmed | A functional near-infrared spectroscopy study on hemodynamic changes of patients with prolonged disorders of consciousness responding to different auditory stimuli |
| title_short | A functional near-infrared spectroscopy study on hemodynamic changes of patients with prolonged disorders of consciousness responding to different auditory stimuli |
| title_sort | functional near infrared spectroscopy study on hemodynamic changes of patients with prolonged disorders of consciousness responding to different auditory stimuli |
| topic | Prolonged disorders of consciousness (pDoC) Functional near-infrared spectroscopy (fNIRS) HbO/HbR Active stimulation Passive stimulation |
| url | https://doi.org/10.1186/s12883-023-03292-6 |
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