IL-12-Induced Immune Suppressive Deficit During CD8+ T-Cell Differentiation

IL-12-Induced Immune Suppressive Deficit During CD8+ T-Cell Differentiation

Autoimmune diseases are characterized by regulatory deficit in both the CD4+ and CD8+ T-cell compartments. We have shown that CD8+ T-cells associated with acute relapse of multiple sclerosis are significantly deficient in their immune suppressive ability. We hypothesized that distinct CD8+ cytotoxic...

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Bibliographic Details
Main Authors: Pranav S. Renavikar, Sushmita Sinha, Ashley A. Brate, Nicholas Borcherding, Michael P. Crawford, Scott M. Steward-Tharp, Nitin J. Karandikar
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
immune regulation
CD8+ T cells
suppressor cells
autoimmunity
Tregs
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.568630/full

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