Digital breast tomosynthesis for breast cancer screening and diagnosis in women with dense breasts – a systematic review and meta-analysis
Abstract Background This study aimed to systematically review and to meta-analyse the accuracy of digital breast tomosynthesis (DBT) versus digital mammography (DM) in women with mammographically dense breasts in screening and diagnosis. Methods Two independent reviewers identified screening or diag...
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| Format: | Article |
| Language: | English |
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BMC
2018-04-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-018-4263-3 |
| _version_ | 1818647965869277184 |
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| author | Xuan-Anh Phi Alberto Tagliafico Nehmat Houssami Marcel J. W. Greuter Geertruida H. de Bock |
| author_facet | Xuan-Anh Phi Alberto Tagliafico Nehmat Houssami Marcel J. W. Greuter Geertruida H. de Bock |
| author_sort | Xuan-Anh Phi |
| collection | DOAJ |
| description | Abstract Background This study aimed to systematically review and to meta-analyse the accuracy of digital breast tomosynthesis (DBT) versus digital mammography (DM) in women with mammographically dense breasts in screening and diagnosis. Methods Two independent reviewers identified screening or diagnostic studies reporting at least one of four outcomes (cancer detection rate-CDR, recall rate, sensitivity and specificity) for DBT and DM in women with mammographically dense breasts. Study quality was assessed using QUADAS-2. Meta-analysis of CDR and recall rate used a random effects model. Summary ROC curve summarized sensitivity and specificity. Results Sixteen studies were included (five diagnostic; eleven screening). In diagnosis, DBT increased sensitivity (84%–90%) versus DM alone (69%–86%) but not specificity. DBT improved CDR versus DM alone (RR: 1.16, 95% CI 1.02–1.31). In screening, DBT + DM increased CDR versus DM alone (RR: 1.33, 95% CI 1.20–1.47 for retrospective studies; RR: 1.52, 95% CI 1.08–2.11 for prospective studies). Recall rate was significantly reduced by DBT + DM in retrospective studies (RR: 0.72, 95% CI 0.64–0.80) but not in two prospective studies (RR: 1.12, 95% CI 0.76–1.63). Conclusion In women with mammographically dense breasts, DBT+/−DM increased CDR significantly (versus DM) in screening and diagnosis. In diagnosis, DBT+/−DM increased sensitivity but not specificity. The effect of DBT + DM on recall rate in screening dense breasts varied between studies. |
| first_indexed | 2024-12-17T01:10:55Z |
| format | Article |
| id | doaj.art-7fb4d11406604771b808f76ad021faa6 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-17T01:10:55Z |
| publishDate | 2018-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-7fb4d11406604771b808f76ad021faa62022-12-21T22:09:09ZengBMCBMC Cancer1471-24072018-04-011811910.1186/s12885-018-4263-3Digital breast tomosynthesis for breast cancer screening and diagnosis in women with dense breasts – a systematic review and meta-analysisXuan-Anh Phi0Alberto Tagliafico1Nehmat Houssami2Marcel J. W. Greuter3Geertruida H. de Bock4Department of Epidemiology, University Medical Center GroningenDepartment of Health Sciences (Dissal), University of Genova and Ospedale Policlinico San MartinoSydney School of Public Health, Sydney Medical School, The University of SydneyDepartment of Radiology, University Medical Center GroningenDepartment of Epidemiology, University Medical Center GroningenAbstract Background This study aimed to systematically review and to meta-analyse the accuracy of digital breast tomosynthesis (DBT) versus digital mammography (DM) in women with mammographically dense breasts in screening and diagnosis. Methods Two independent reviewers identified screening or diagnostic studies reporting at least one of four outcomes (cancer detection rate-CDR, recall rate, sensitivity and specificity) for DBT and DM in women with mammographically dense breasts. Study quality was assessed using QUADAS-2. Meta-analysis of CDR and recall rate used a random effects model. Summary ROC curve summarized sensitivity and specificity. Results Sixteen studies were included (five diagnostic; eleven screening). In diagnosis, DBT increased sensitivity (84%–90%) versus DM alone (69%–86%) but not specificity. DBT improved CDR versus DM alone (RR: 1.16, 95% CI 1.02–1.31). In screening, DBT + DM increased CDR versus DM alone (RR: 1.33, 95% CI 1.20–1.47 for retrospective studies; RR: 1.52, 95% CI 1.08–2.11 for prospective studies). Recall rate was significantly reduced by DBT + DM in retrospective studies (RR: 0.72, 95% CI 0.64–0.80) but not in two prospective studies (RR: 1.12, 95% CI 0.76–1.63). Conclusion In women with mammographically dense breasts, DBT+/−DM increased CDR significantly (versus DM) in screening and diagnosis. In diagnosis, DBT+/−DM increased sensitivity but not specificity. The effect of DBT + DM on recall rate in screening dense breasts varied between studies.http://link.springer.com/article/10.1186/s12885-018-4263-3Breast neoplasmDigital mammographyDigital breast tomosynthesisReviewMeta-analysisBreast density |
| spellingShingle | Xuan-Anh Phi Alberto Tagliafico Nehmat Houssami Marcel J. W. Greuter Geertruida H. de Bock Digital breast tomosynthesis for breast cancer screening and diagnosis in women with dense breasts – a systematic review and meta-analysis BMC Cancer Breast neoplasm Digital mammography Digital breast tomosynthesis Review Meta-analysis Breast density |
| title | Digital breast tomosynthesis for breast cancer screening and diagnosis in women with dense breasts – a systematic review and meta-analysis |
| title_full | Digital breast tomosynthesis for breast cancer screening and diagnosis in women with dense breasts – a systematic review and meta-analysis |
| title_fullStr | Digital breast tomosynthesis for breast cancer screening and diagnosis in women with dense breasts – a systematic review and meta-analysis |
| title_full_unstemmed | Digital breast tomosynthesis for breast cancer screening and diagnosis in women with dense breasts – a systematic review and meta-analysis |
| title_short | Digital breast tomosynthesis for breast cancer screening and diagnosis in women with dense breasts – a systematic review and meta-analysis |
| title_sort | digital breast tomosynthesis for breast cancer screening and diagnosis in women with dense breasts a systematic review and meta analysis |
| topic | Breast neoplasm Digital mammography Digital breast tomosynthesis Review Meta-analysis Breast density |
| url | http://link.springer.com/article/10.1186/s12885-018-4263-3 |
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