Statins: The paradigm shift in periodontal regeneration
Statins, the lipid-lowering drugs, provide an important and effective approach for the treatment of hyperlipidemia and arteriosclerosis. They function by reducing the blood cholesterol levels which came as a marked discovery to intervene in cardiovascular and cerebrovascular diseases related to incr...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-01-01
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| Series: | SRM Journal of Research in Dental Sciences |
| Subjects: | |
| Online Access: | http://www.srmjrds.in/article.asp?issn=0976-433X;year=2014;volume=5;issue=1;spage=26;epage=30;aulast=Kataria |
| _version_ | 1798005153654112256 |
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| author | Prerna Kataria Jasmine Kaur Eram Parvez R P Maurya |
| author_facet | Prerna Kataria Jasmine Kaur Eram Parvez R P Maurya |
| author_sort | Prerna Kataria |
| collection | DOAJ |
| description | Statins, the lipid-lowering drugs, provide an important and effective approach for the treatment of hyperlipidemia and arteriosclerosis. They function by reducing the blood cholesterol levels which came as a marked discovery to intervene in cardiovascular and cerebrovascular diseases related to increased lipid levels. Their long-term systemic administration in humans has been shown to result in increased bone mineral density. In recent scenario, statins thus modulate bone metabolism exhibiting antibone resorbing properties by upregulating the bone morphogenic proteins and blocking the intermediate metabolites of the mevalonate pathway, made evident by various in vivo and in vitro studies thus providing a new direction in the field of periodontal regeneration. Statins also offered the added advantage of anti-inflammatory and antioxidant properties. Thus, the use of statins both systemically and locally gained wide acceptance by the periodontists as they have shown to increase the bone mineral density and may be effective for periodontal regeneration by stimulation of regenerative factors. This article reviews the beneficial effect of statins and examines their potential role in regenerative periodontal therapy. |
| first_indexed | 2024-04-11T12:34:32Z |
| format | Article |
| id | doaj.art-7fb52c84922a4f8b85a58b73bb304aba |
| institution | Directory Open Access Journal |
| issn | 2772-5243 2772-5251 |
| language | English |
| last_indexed | 2024-04-11T12:34:32Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | SRM Journal of Research in Dental Sciences |
| spelling | doaj.art-7fb52c84922a4f8b85a58b73bb304aba2022-12-22T04:23:40ZengWolters Kluwer Medknow PublicationsSRM Journal of Research in Dental Sciences2772-52432772-52512014-01-0151263010.4103/0976-433X.129069Statins: The paradigm shift in periodontal regenerationPrerna KatariaJasmine KaurEram ParvezR P MauryaStatins, the lipid-lowering drugs, provide an important and effective approach for the treatment of hyperlipidemia and arteriosclerosis. They function by reducing the blood cholesterol levels which came as a marked discovery to intervene in cardiovascular and cerebrovascular diseases related to increased lipid levels. Their long-term systemic administration in humans has been shown to result in increased bone mineral density. In recent scenario, statins thus modulate bone metabolism exhibiting antibone resorbing properties by upregulating the bone morphogenic proteins and blocking the intermediate metabolites of the mevalonate pathway, made evident by various in vivo and in vitro studies thus providing a new direction in the field of periodontal regeneration. Statins also offered the added advantage of anti-inflammatory and antioxidant properties. Thus, the use of statins both systemically and locally gained wide acceptance by the periodontists as they have shown to increase the bone mineral density and may be effective for periodontal regeneration by stimulation of regenerative factors. This article reviews the beneficial effect of statins and examines their potential role in regenerative periodontal therapy.http://www.srmjrds.in/article.asp?issn=0976-433X;year=2014;volume=5;issue=1;spage=26;epage=30;aulast=Katariabone morphogenic proteinsperiodontal regenerationperiodontitisstatins |
| spellingShingle | Prerna Kataria Jasmine Kaur Eram Parvez R P Maurya Statins: The paradigm shift in periodontal regeneration SRM Journal of Research in Dental Sciences bone morphogenic proteins periodontal regeneration periodontitis statins |
| title | Statins: The paradigm shift in periodontal regeneration |
| title_full | Statins: The paradigm shift in periodontal regeneration |
| title_fullStr | Statins: The paradigm shift in periodontal regeneration |
| title_full_unstemmed | Statins: The paradigm shift in periodontal regeneration |
| title_short | Statins: The paradigm shift in periodontal regeneration |
| title_sort | statins the paradigm shift in periodontal regeneration |
| topic | bone morphogenic proteins periodontal regeneration periodontitis statins |
| url | http://www.srmjrds.in/article.asp?issn=0976-433X;year=2014;volume=5;issue=1;spage=26;epage=30;aulast=Kataria |
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