Andrographolide : Potency as Antiatherosclerosis in Il-1β Cytokine
The focus is how the role of cytokines in atherosclerosis as a chronic inflammatory disease, as it is known that cytokines regulate complex inflammatory responses in atherosclerotic plaques, especially IL-1β. Sambiloto (Andrographis paniculata) is a plant with various pharmacological activities. And...
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| Format: | Article |
| Language: | English |
| Published: |
Lembaga Penelitian dan Pengabdian Masyarakat (LP2M)
2023-06-01
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| Series: | Jurnal Ilmiah Kesehatan Sandi Husada |
| Subjects: | |
| Online Access: | https://akper-sandikarsa.e-journal.id/JIKSH/article/view/991 |
| _version_ | 1828715845448105984 |
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| author | Putu Yudha Ugrasena Iwan Saka Nugraha Ni Wayan Rika Kumara Dewi |
| author_facet | Putu Yudha Ugrasena Iwan Saka Nugraha Ni Wayan Rika Kumara Dewi |
| author_sort | Putu Yudha Ugrasena |
| collection | DOAJ |
| description | The focus is how the role of cytokines in atherosclerosis as a chronic inflammatory disease, as it is known that cytokines regulate complex inflammatory responses in atherosclerotic plaques, especially IL-1β. Sambiloto (Andrographis paniculata) is a plant with various pharmacological activities. Andrographolide (AND) is the main bioactive compound in the diterpene lactone group. This literature study aims to assess the potential of AND on the proinflammatory cytokine IL-1 β as an antiatherosclerosis. This type of research is a qualitative review of various studies using sambiloto plants or andrographolide compounds (AND). Search literature using the Google Scholar database. Keywords used "Andrographis paniculata, andrographolide, IL-1β, Atherosclerosis. The results showed that AND has effects as an anti-inflammatory, antiatherosclerosis as well as cardiovascular-related diseases. There are not many articles on the activity of AND in IL-1β against atherosclerosis, but AND can provide inhibitory activity of the cytokine IL-1β against inflammation. Not many researchers have discussed the pharmacological effects of AND as an antiatherosclerotic on IL-1β therapeutic targets, but from the results of the review AND has a strong potential in inhibiting IL-1 cytokine secretion β. |
| first_indexed | 2024-03-11T16:56:25Z |
| format | Article |
| id | doaj.art-7fb9c8c9a55f49628744a2c18f833818 |
| institution | Directory Open Access Journal |
| issn | 2354-6093 2654-4563 |
| language | English |
| last_indexed | 2024-03-11T16:56:25Z |
| publishDate | 2023-06-01 |
| publisher | Lembaga Penelitian dan Pengabdian Masyarakat (LP2M) |
| record_format | Article |
| series | Jurnal Ilmiah Kesehatan Sandi Husada |
| spelling | doaj.art-7fb9c8c9a55f49628744a2c18f8338182023-10-20T14:55:13ZengLembaga Penelitian dan Pengabdian Masyarakat (LP2M)Jurnal Ilmiah Kesehatan Sandi Husada2354-60932654-45632023-06-0112119020010.35816/jiskh.v12i1.991991Andrographolide : Potency as Antiatherosclerosis in Il-1β CytokinePutu Yudha Ugrasena0Iwan Saka Nugraha1Ni Wayan Rika Kumara Dewi2Institut Teknologi dan Kesehatan Bintang PersadaInstitut Teknologi dan Kesehatan Bintang PersadaInstitut Teknologi dan Kesehatan Bintang PersadaThe focus is how the role of cytokines in atherosclerosis as a chronic inflammatory disease, as it is known that cytokines regulate complex inflammatory responses in atherosclerotic plaques, especially IL-1β. Sambiloto (Andrographis paniculata) is a plant with various pharmacological activities. Andrographolide (AND) is the main bioactive compound in the diterpene lactone group. This literature study aims to assess the potential of AND on the proinflammatory cytokine IL-1 β as an antiatherosclerosis. This type of research is a qualitative review of various studies using sambiloto plants or andrographolide compounds (AND). Search literature using the Google Scholar database. Keywords used "Andrographis paniculata, andrographolide, IL-1β, Atherosclerosis. The results showed that AND has effects as an anti-inflammatory, antiatherosclerosis as well as cardiovascular-related diseases. There are not many articles on the activity of AND in IL-1β against atherosclerosis, but AND can provide inhibitory activity of the cytokine IL-1β against inflammation. Not many researchers have discussed the pharmacological effects of AND as an antiatherosclerotic on IL-1β therapeutic targets, but from the results of the review AND has a strong potential in inhibiting IL-1 cytokine secretion β.https://akper-sandikarsa.e-journal.id/JIKSH/article/view/991andrographis paniculataandrographolideatherosclerosis,il-1β |
| spellingShingle | Putu Yudha Ugrasena Iwan Saka Nugraha Ni Wayan Rika Kumara Dewi Andrographolide : Potency as Antiatherosclerosis in Il-1β Cytokine Jurnal Ilmiah Kesehatan Sandi Husada andrographis paniculata andrographolide atherosclerosis, il-1β |
| title | Andrographolide : Potency as Antiatherosclerosis in Il-1β Cytokine |
| title_full | Andrographolide : Potency as Antiatherosclerosis in Il-1β Cytokine |
| title_fullStr | Andrographolide : Potency as Antiatherosclerosis in Il-1β Cytokine |
| title_full_unstemmed | Andrographolide : Potency as Antiatherosclerosis in Il-1β Cytokine |
| title_short | Andrographolide : Potency as Antiatherosclerosis in Il-1β Cytokine |
| title_sort | andrographolide potency as antiatherosclerosis in il 1β cytokine |
| topic | andrographis paniculata andrographolide atherosclerosis, il-1β |
| url | https://akper-sandikarsa.e-journal.id/JIKSH/article/view/991 |
| work_keys_str_mv | AT putuyudhaugrasena andrographolidepotencyasantiatherosclerosisinil1bcytokine AT iwansakanugraha andrographolidepotencyasantiatherosclerosisinil1bcytokine AT niwayanrikakumaradewi andrographolidepotencyasantiatherosclerosisinil1bcytokine |