Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors
Tyrosine kinase inhibitors (TKIs) have become first-line drugs for cancer treatment. However, their clinical use is seriously hindered since many patients experience diarrhea after receiving TKIs. The mechanisms of TKI-associated diarrhea remain unclear. Most existing therapies are symptomatic treat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S240584402403562X |
| _version_ | 1827294046729535488 |
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| author | Jiangnan Liu Shuai Yan Juntong Du Lizhi Teng Ru Yang Peng Xu Weiyang Tao |
| author_facet | Jiangnan Liu Shuai Yan Juntong Du Lizhi Teng Ru Yang Peng Xu Weiyang Tao |
| author_sort | Jiangnan Liu |
| collection | DOAJ |
| description | Tyrosine kinase inhibitors (TKIs) have become first-line drugs for cancer treatment. However, their clinical use is seriously hindered since many patients experience diarrhea after receiving TKIs. The mechanisms of TKI-associated diarrhea remain unclear. Most existing therapies are symptomatic treatments based on experience and their effects are unsatisfactory. Therefore, clarification of the mechanisms underlying diarrhea is critical to develop effective anti-diarrhea drugs. This article summarizes several potential mechanisms of TKI-associated diarrhea and reviews current treatment progress. |
| first_indexed | 2024-04-24T13:50:30Z |
| format | Article |
| id | doaj.art-7fba04c5f007468ba108dd6bcdf19b7b |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:50:30Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-7fba04c5f007468ba108dd6bcdf19b7b2024-04-04T05:05:03ZengElsevierHeliyon2405-84402024-03-01106e27531Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitorsJiangnan Liu0Shuai Yan1Juntong Du2Lizhi Teng3Ru Yang4Peng Xu5Weiyang Tao6Department of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, Heilongjiang, 150001, PR China; Key Laboratory of Acoustic, Optical and Electromagnetic Diagnosis and Treatment of Cardiovascular Diseases, Heilongjiang, 150001, PR China; The Cell Transplantation Key Laboratory of National Health Commission, Heilongjiang, 150001, PR ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, Heilongjiang, 150001, PR China; Key Laboratory of Acoustic, Optical and Electromagnetic Diagnosis and Treatment of Cardiovascular Diseases, Heilongjiang, 150001, PR China; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang, 150001, PR China; The Cell Transplantation Key Laboratory of National Health Commission, Heilongjiang, 150001, PR ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, Heilongjiang, 150001, PR China; Key Laboratory of Acoustic, Optical and Electromagnetic Diagnosis and Treatment of Cardiovascular Diseases, Heilongjiang, 150001, PR China; The Cell Transplantation Key Laboratory of National Health Commission, Heilongjiang, 150001, PR ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, Heilongjiang, 150001, PR China; Key Laboratory of Acoustic, Optical and Electromagnetic Diagnosis and Treatment of Cardiovascular Diseases, Heilongjiang, 150001, PR China; The Cell Transplantation Key Laboratory of National Health Commission, Heilongjiang, 150001, PR ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, Heilongjiang, 150001, PR China; Key Laboratory of Acoustic, Optical and Electromagnetic Diagnosis and Treatment of Cardiovascular Diseases, Heilongjiang, 150001, PR China; The Cell Transplantation Key Laboratory of National Health Commission, Heilongjiang, 150001, PR ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, Heilongjiang, 150001, PR China; Key Laboratory of Acoustic, Optical and Electromagnetic Diagnosis and Treatment of Cardiovascular Diseases, Heilongjiang, 150001, PR China; The Cell Transplantation Key Laboratory of National Health Commission, Heilongjiang, 150001, PR ChinaDepartment of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, Heilongjiang, 150001, PR China; Key Laboratory of Acoustic, Optical and Electromagnetic Diagnosis and Treatment of Cardiovascular Diseases, Heilongjiang, 150001, PR China; Key Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang, 150001, PR China; The Cell Transplantation Key Laboratory of National Health Commission, Heilongjiang, 150001, PR China; Corresponding author. Department of Breast Surgery, The First Affiliated Hospital of Harbin Medical University, No. 23, Youzheng Street, Nangang District, Harbin, 150001, PR China.Tyrosine kinase inhibitors (TKIs) have become first-line drugs for cancer treatment. However, their clinical use is seriously hindered since many patients experience diarrhea after receiving TKIs. The mechanisms of TKI-associated diarrhea remain unclear. Most existing therapies are symptomatic treatments based on experience and their effects are unsatisfactory. Therefore, clarification of the mechanisms underlying diarrhea is critical to develop effective anti-diarrhea drugs. This article summarizes several potential mechanisms of TKI-associated diarrhea and reviews current treatment progress.http://www.sciencedirect.com/science/article/pii/S240584402403562XTyrosine kinase inhibitorsDiarrheaMechanismTreatment |
| spellingShingle | Jiangnan Liu Shuai Yan Juntong Du Lizhi Teng Ru Yang Peng Xu Weiyang Tao Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors Heliyon Tyrosine kinase inhibitors Diarrhea Mechanism Treatment |
| title | Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors |
| title_full | Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors |
| title_fullStr | Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors |
| title_full_unstemmed | Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors |
| title_short | Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors |
| title_sort | mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors |
| topic | Tyrosine kinase inhibitors Diarrhea Mechanism Treatment |
| url | http://www.sciencedirect.com/science/article/pii/S240584402403562X |
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