tRNAs as regulators of biological processes
Transfer RNAs (tRNA) are best known for their role as adaptors during translation of the genetic code. Beyond their canonical role during protein biosynthesis, tRNAs also perform additional functions in both prokaryotes and eukaryotes for example in regulating gene expression. Aminoacylated tRNAs ha...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-06-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00171/full |
| _version_ | 1811303139161145344 |
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| author | Medha eRaina Michael eIbba |
| author_facet | Medha eRaina Michael eIbba |
| author_sort | Medha eRaina |
| collection | DOAJ |
| description | Transfer RNAs (tRNA) are best known for their role as adaptors during translation of the genetic code. Beyond their canonical role during protein biosynthesis, tRNAs also perform additional functions in both prokaryotes and eukaryotes for example in regulating gene expression. Aminoacylated tRNAs have also been implicated as substrates for non-ribosomal peptide bond formation, post-translational protein labeling, modification of phospholipids in the cell membrane and antibiotic biosyntheses. Most recently tRNA fragments, or tRFs, have also been recognized to play regulatory roles. Here we examine in more details some of the new functions emerging for tRNA in a variety of cellular processes outside of protein synthesis. |
| first_indexed | 2024-04-13T07:41:25Z |
| format | Article |
| id | doaj.art-7fbada2ab8cd44429cae8d00b9f7b404 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-13T07:41:25Z |
| publishDate | 2014-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-7fbada2ab8cd44429cae8d00b9f7b4042022-12-22T02:55:52ZengFrontiers Media S.A.Frontiers in Genetics1664-80212014-06-01510.3389/fgene.2014.0017192747tRNAs as regulators of biological processesMedha eRaina0Michael eIbba1Ohio State UniversityOhio State UniversityTransfer RNAs (tRNA) are best known for their role as adaptors during translation of the genetic code. Beyond their canonical role during protein biosynthesis, tRNAs also perform additional functions in both prokaryotes and eukaryotes for example in regulating gene expression. Aminoacylated tRNAs have also been implicated as substrates for non-ribosomal peptide bond formation, post-translational protein labeling, modification of phospholipids in the cell membrane and antibiotic biosyntheses. Most recently tRNA fragments, or tRFs, have also been recognized to play regulatory roles. Here we examine in more details some of the new functions emerging for tRNA in a variety of cellular processes outside of protein synthesis.http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00171/fullregulationAmino acidprotein synthesistranslationtransfer RNA |
| spellingShingle | Medha eRaina Michael eIbba tRNAs as regulators of biological processes Frontiers in Genetics regulation Amino acid protein synthesis translation transfer RNA |
| title | tRNAs as regulators of biological processes |
| title_full | tRNAs as regulators of biological processes |
| title_fullStr | tRNAs as regulators of biological processes |
| title_full_unstemmed | tRNAs as regulators of biological processes |
| title_short | tRNAs as regulators of biological processes |
| title_sort | trnas as regulators of biological processes |
| topic | regulation Amino acid protein synthesis translation transfer RNA |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00171/full |
| work_keys_str_mv | AT medhaeraina trnasasregulatorsofbiologicalprocesses AT michaeleibba trnasasregulatorsofbiologicalprocesses |