Calycosin and Genistein Induce Apoptosis by Inactivation of HOTAIR/p-Akt Signaling Pathway in Human Breast Cancer MCF-7 Cells

Calycosin and Genistein Induce Apoptosis by Inactivation of HOTAIR/p-Akt Signaling Pathway in Human Breast Cancer MCF-7 Cells

Background: Calycosin and genistein are the two main components of isoflavones. Previously, we reported that these compounds display antitumor activities in the breast cancer cell lines MCF-7 and T47D. In the present study, we investigated the mechanism of action of calycosin and genistein, and thei...

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Bibliographic Details
Main Authors: Jian Chen, Changrong Lin, Wang Yong, Yu Ye, Zhaoquan Huang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
Calycosin
Genistein apoptosis
HOTAIR
p-Akt
Online Access:http://www.karger.com/Article/FullText/369732

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