Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer
There is increasing evidence of the role of endocrine disruptors (EDs) derived from commonly employed compounds for manufacturing and processing in altering hormonal signaling and function. Due to their prolonged half-life and persistence, EDs can usually be found not only in industrial products but...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/17/4237 |
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| author | Valerio Renzelli Marco Gallo Lelio Morviducci Giampiero Marino Alberto Ragni Enzo Tuveri Antongiulio Faggiano Rossella Mazzilli Annalisa Natalicchio Maria Chiara Zatelli Monica Montagnani Stefano Fogli Dario Giuffrida Antonella Argentiero Romano Danesi Stella D’Oronzo Stefania Gori Tindara Franchina Antonio Russo Matteo Monami Laura Sciacca Saverio Cinieri Annamaria Colao Angelo Avogaro Graziano Di Cianni Francesco Giorgino Nicola Silvestris |
| author_facet | Valerio Renzelli Marco Gallo Lelio Morviducci Giampiero Marino Alberto Ragni Enzo Tuveri Antongiulio Faggiano Rossella Mazzilli Annalisa Natalicchio Maria Chiara Zatelli Monica Montagnani Stefano Fogli Dario Giuffrida Antonella Argentiero Romano Danesi Stella D’Oronzo Stefania Gori Tindara Franchina Antonio Russo Matteo Monami Laura Sciacca Saverio Cinieri Annamaria Colao Angelo Avogaro Graziano Di Cianni Francesco Giorgino Nicola Silvestris |
| author_sort | Valerio Renzelli |
| collection | DOAJ |
| description | There is increasing evidence of the role of endocrine disruptors (EDs) derived from commonly employed compounds for manufacturing and processing in altering hormonal signaling and function. Due to their prolonged half-life and persistence, EDs can usually be found not only in industrial products but also in households and in the environment, creating the premises for long-lasting exposure. Polybrominated diphenyl ethers (PBDEs) are common EDs used in industrial products such as flame retardants, and recent studies are increasingly showing that they may interfere with both metabolic and oncogenic pathways. In this article, a multidisciplinary panel of experts of the Italian Association of Medical Diabetologists (AMD), the Italian Society of Diabetology (SID), the Italian Association of Medical Oncology (AIOM), the Italian Society of Endocrinology (SIE) and the Italian Society of Pharmacology (SIF) provides a review on the potential role of PBDEs in human health and disease, exploring both molecular and clinical aspects and focusing on metabolic and oncogenic pathways. |
| first_indexed | 2024-03-10T23:26:49Z |
| format | Article |
| id | doaj.art-7fbe6c90901f4cce988c2c90dc3121d2 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T23:26:49Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-7fbe6c90901f4cce988c2c90dc3121d22023-11-19T07:55:02ZengMDPI AGCancers2072-66942023-08-011517423710.3390/cancers15174237Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and CancerValerio Renzelli0Marco Gallo1Lelio Morviducci2Giampiero Marino3Alberto Ragni4Enzo Tuveri5Antongiulio Faggiano6Rossella Mazzilli7Annalisa Natalicchio8Maria Chiara Zatelli9Monica Montagnani10Stefano Fogli11Dario Giuffrida12Antonella Argentiero13Romano Danesi14Stella D’Oronzo15Stefania Gori16Tindara Franchina17Antonio Russo18Matteo Monami19Laura Sciacca20Saverio Cinieri21Annamaria Colao22Angelo Avogaro23Graziano Di Cianni24Francesco Giorgino25Nicola Silvestris26Italian Association of Clinical Diabetologists, 00192 Rome, ItalyEndocrinology and Metabolic Diseases Unit, AO SS Antonio e Biagio e Cesare Arrigo of Alessandria, 15121 Alessandria, ItalyDiabetology and Nutrition Unit, Department of Medical Specialities, ASL Roma 1, S. Spirito Hospital, 00193 Rome, ItalyInternal Medicine Department, Ospedale dei Castelli, Asl Roma 6, 00040 Ariccia, ItalyEndocrinology and Metabolic Diseases Unit, AO SS Antonio e Biagio e Cesare Arrigo of Alessandria, 15121 Alessandria, ItalyDiabetology, Endocrinology and Metabolic Diseases Service, ASL-Sulcis, 09016 Iglesias, ItalyEndocrinology Unit, Department of Clinical & Molecular Medicine, Sant’Andrea Hospital, Sapienza University of Rome, 00189 Rome, ItalyEndocrinology Unit, Department of Clinical & Molecular Medicine, Sant’Andrea Hospital, Sapienza University of Rome, 00189 Rome, ItalyDepartment of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, 70121 Bari, ItalySection of Endocrinology, Geriatrics and Internal Medicine, Department of Medical Sciences, University of Ferrara, 44121 Ferrara, ItalyDepartment of Precision and Regenerative Medicine and Ionian Area, Section of Pharmacology, University of Bari Aldo Moro, 70121 Bari, ItalyClinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyDepartment of Oncology, Istituto Oncologico del Mediterraneo, Viagrande, 95029 Catania, ItalyMedical Oncology Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, 70124 Bari, ItalyClinical Pharmacology and Pharmacogenetics Unit, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, ItalyInterdisciplinary Department of Medicine, University of Bari Aldo Moro, 70121 Bari, ItalyOncologia Medica, IRCCS Ospedale Don Calabria-Sacro Cuore di Negrar, 37024 Verona, ItalyMedical Oncology Unit, Department of Human Pathology “G. Barresi”, University of Messina, 98122 Messina, ItalyDepartment of Surgical, Oncological and Oral Sciences, Section of Medical Oncology, University of Palermo, 90133 Palermo, ItalyDiabetology, Careggi University Hospital, University of Florence, 50134 Florence, ItalyDepartment of Clinical and Experimental Medicine, Endocrinology Section, University of Catania, 95124 Catania, ItalyMedical Oncology Division, Breast Unit, Senatore Antonio Perrino Hospital, ASL Brindisi, 72100 Brindisi, ItalyEndocrinology, Diabetology and Andrology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, 80138 Naples, ItalyDepartment of Medicine, Section of Diabetes and Metabolic Diseases, University of Padova, 35122 Padova, ItalyDiabetes Unit, Livorno Hospital, 57100 Livorno, ItalyDepartment of Precision and Regenerative Medicine and Ionian Area, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, 70121 Bari, ItalyMedical Oncology Unit, Department of Human Pathology “G. Barresi”, University of Messina, 98122 Messina, ItalyThere is increasing evidence of the role of endocrine disruptors (EDs) derived from commonly employed compounds for manufacturing and processing in altering hormonal signaling and function. Due to their prolonged half-life and persistence, EDs can usually be found not only in industrial products but also in households and in the environment, creating the premises for long-lasting exposure. Polybrominated diphenyl ethers (PBDEs) are common EDs used in industrial products such as flame retardants, and recent studies are increasingly showing that they may interfere with both metabolic and oncogenic pathways. In this article, a multidisciplinary panel of experts of the Italian Association of Medical Diabetologists (AMD), the Italian Society of Diabetology (SID), the Italian Association of Medical Oncology (AIOM), the Italian Society of Endocrinology (SIE) and the Italian Society of Pharmacology (SIF) provides a review on the potential role of PBDEs in human health and disease, exploring both molecular and clinical aspects and focusing on metabolic and oncogenic pathways.https://www.mdpi.com/2072-6694/15/17/4237PBDEendocrine disruptorsenvironmentmetabolismdiabetesobesity |
| spellingShingle | Valerio Renzelli Marco Gallo Lelio Morviducci Giampiero Marino Alberto Ragni Enzo Tuveri Antongiulio Faggiano Rossella Mazzilli Annalisa Natalicchio Maria Chiara Zatelli Monica Montagnani Stefano Fogli Dario Giuffrida Antonella Argentiero Romano Danesi Stella D’Oronzo Stefania Gori Tindara Franchina Antonio Russo Matteo Monami Laura Sciacca Saverio Cinieri Annamaria Colao Angelo Avogaro Graziano Di Cianni Francesco Giorgino Nicola Silvestris Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer Cancers PBDE endocrine disruptors environment metabolism diabetes obesity |
| title | Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer |
| title_full | Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer |
| title_fullStr | Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer |
| title_full_unstemmed | Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer |
| title_short | Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer |
| title_sort | polybrominated diphenyl ethers pbdes and human health effects on metabolism diabetes and cancer |
| topic | PBDE endocrine disruptors environment metabolism diabetes obesity |
| url | https://www.mdpi.com/2072-6694/15/17/4237 |
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