Engineering a norcoclaurine synthase for one-step synthesis of (S)-1-aryl-tetrahydroisoquinolines

Engineering a norcoclaurine synthase for one-step synthesis of (S)-1-aryl-tetrahydroisoquinolines

Abstract Tetrahydroisoquinoline alkaloids (THIQAs) are ubiquitous compounds with important pharmaceutical and biological activity. Their key N-heterocyclic structural motifs are synthesised via Pictet–Spengler (P–S) reaction by norcoclaurine synthases (NCS) in plants. The synthesis of 1-aryl-tetrahy...

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Bibliographic Details
Main Authors: Man Zhang, Zheng-Yu Huang, Ying Su, Fei-Fei Chen, Qi Chen, Jian-He Xu, Gao-Wei Zheng
Format: Article
Language:English
Published: SpringerOpen 2023-03-01
Series:Bioresources and Bioprocessing
Subjects:
Biocatalysis
Norcoclaurine synthase
Protein engineering
Pictet–Spengler reaction
Tetrahydroisoquinoline alkaloids
Online Access:https://doi.org/10.1186/s40643-023-00637-4

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