Tamoxifen therapy in a murine model of myotubular myopathy
Myotubular myopathy is a severe muscle disease for which no effective treatment exists. Here, the authors show that tamoxifen ameliorates pathology and extends survival in a mouse model of the disease, and that the effect is mediated via estrogen receptor signaling and involves modulation of DNM2 ex...
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Bibliographic Details
| Main Authors: |
Nika Maani,
Nesrin Sabha,
Kamran Rezai,
Arun Ramani,
Linda Groom,
Nadine Eltayeb,
Faranak Mavandadnejad,
Andrea Pang,
Giulia Russo,
Michael Brudno,
Volker Haucke,
Robert T. Dirksen,
James J. Dowling |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2018-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-07057-5
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