Test-retest variability of resting-state networks in healthy aging and prodromal Alzheimer's disease
In recent years, changes in resting-state networks (RSN), identified by functional magnetic resonance imaging (fMRI), have gained increasing attention as potential biomarkers and trackers of neurological disorders such as Alzheimer's disease (AD). Intersession reliability of RSN is fundamental...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218301992 |
| _version_ | 1811230908172206080 |
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| author | K. Conwell B. von Reutern N. Richter J. Kukolja G.R. Fink O.A. Onur |
| author_facet | K. Conwell B. von Reutern N. Richter J. Kukolja G.R. Fink O.A. Onur |
| author_sort | K. Conwell |
| collection | DOAJ |
| description | In recent years, changes in resting-state networks (RSN), identified by functional magnetic resonance imaging (fMRI), have gained increasing attention as potential biomarkers and trackers of neurological disorders such as Alzheimer's disease (AD). Intersession reliability of RSN is fundamental to this approach.In this study, we investigated the test-retest reliability of three memory related RSN (i.e., the default mode, salience, and executive control network) in 15 young, 15 healthy seniors (HS), and 15 subjects affected by mild cognitive impairment (MCI) with positive biomarkers suggestive of incipient AD (6 females each). FMRI was conducted on three separate occasions. Independent Component Analysis decomposed the resting-state data into RSNs. Comparisons of variation in functional connectivity between groups were made applying different thresholds in an explorative approach. Intersession test-retest reliability was evaluated by intraclass correlation coefficient (ICC) comparisons. To assess the effect of gray matter volume loss, motion, cerebrospinal fluid based biomarkers and the time gap between sessions on intersession variation, the former four were correlated separately with the latter.Data showed that i) young subjects ICCs (relative to HS/MCI-subjects) had higher intersession reliability, ii) stringent statistical thresholds need to be applied to prevent false-positives, iii) both HS and MCI-subjects (relative to young) showed significantly more clusters of intersession variation in all three RSN, iv) while intersession variation was highly correlated with head motion, it was also correlated with biomarkers (especially phospho-tau), the time gap between sessions and local GMV. Results indicate that time gaps between sessions should be kept constant and that head motion must be taken into account when using RSN to assess aging and neurodegeneration. In patients with prodromal AD, re-test reliability may be increased by accouting for overall disease burden by including biomarkers of neuronal injury (especially phospho-tau) in statistical analyses. Local atrophy however, does not seem to play a major role in regards to reliability, but should be used as covariate depending on the research question. Keywords: ICA, MCI, fMRI, DMN |
| first_indexed | 2024-04-12T10:35:54Z |
| format | Article |
| id | doaj.art-7fc11fa1046448b693f6a53e5a500a10 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-12T10:35:54Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-7fc11fa1046448b693f6a53e5a500a102022-12-22T03:36:42ZengElsevierNeuroImage: Clinical2213-15822018-01-0119948962Test-retest variability of resting-state networks in healthy aging and prodromal Alzheimer's diseaseK. Conwell0B. von Reutern1N. Richter2J. Kukolja3G.R. Fink4O.A. Onur5Department of Neurology, University Hospital of Cologne, Cologne 50937, Germany; Department of General, Abdominal, Endocrine and Minimally Invasive Surgery, Academic Hospital Bogenhausen, 81925 Munich, GermanyDepartment of Neurology, University Hospital of Cologne, Cologne 50937, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre, Jülich 52428, GermanyDepartment of Neurology, University Hospital of Cologne, Cologne 50937, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre, Jülich 52428, GermanyDepartment of Neurology, University Hospital of Cologne, Cologne 50937, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre, Jülich 52428, GermanyDepartment of Neurology, University Hospital of Cologne, Cologne 50937, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre, Jülich 52428, GermanyDepartment of Neurology, University Hospital of Cologne, Cologne 50937, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre, Jülich 52428, Germany; Corresponding author at: Department of Neurology, University Hospital of Cologne, Kerpener Str. 62, 50937 Köln, Germany.In recent years, changes in resting-state networks (RSN), identified by functional magnetic resonance imaging (fMRI), have gained increasing attention as potential biomarkers and trackers of neurological disorders such as Alzheimer's disease (AD). Intersession reliability of RSN is fundamental to this approach.In this study, we investigated the test-retest reliability of three memory related RSN (i.e., the default mode, salience, and executive control network) in 15 young, 15 healthy seniors (HS), and 15 subjects affected by mild cognitive impairment (MCI) with positive biomarkers suggestive of incipient AD (6 females each). FMRI was conducted on three separate occasions. Independent Component Analysis decomposed the resting-state data into RSNs. Comparisons of variation in functional connectivity between groups were made applying different thresholds in an explorative approach. Intersession test-retest reliability was evaluated by intraclass correlation coefficient (ICC) comparisons. To assess the effect of gray matter volume loss, motion, cerebrospinal fluid based biomarkers and the time gap between sessions on intersession variation, the former four were correlated separately with the latter.Data showed that i) young subjects ICCs (relative to HS/MCI-subjects) had higher intersession reliability, ii) stringent statistical thresholds need to be applied to prevent false-positives, iii) both HS and MCI-subjects (relative to young) showed significantly more clusters of intersession variation in all three RSN, iv) while intersession variation was highly correlated with head motion, it was also correlated with biomarkers (especially phospho-tau), the time gap between sessions and local GMV. Results indicate that time gaps between sessions should be kept constant and that head motion must be taken into account when using RSN to assess aging and neurodegeneration. In patients with prodromal AD, re-test reliability may be increased by accouting for overall disease burden by including biomarkers of neuronal injury (especially phospho-tau) in statistical analyses. Local atrophy however, does not seem to play a major role in regards to reliability, but should be used as covariate depending on the research question. Keywords: ICA, MCI, fMRI, DMNhttp://www.sciencedirect.com/science/article/pii/S2213158218301992 |
| spellingShingle | K. Conwell B. von Reutern N. Richter J. Kukolja G.R. Fink O.A. Onur Test-retest variability of resting-state networks in healthy aging and prodromal Alzheimer's disease NeuroImage: Clinical |
| title | Test-retest variability of resting-state networks in healthy aging and prodromal Alzheimer's disease |
| title_full | Test-retest variability of resting-state networks in healthy aging and prodromal Alzheimer's disease |
| title_fullStr | Test-retest variability of resting-state networks in healthy aging and prodromal Alzheimer's disease |
| title_full_unstemmed | Test-retest variability of resting-state networks in healthy aging and prodromal Alzheimer's disease |
| title_short | Test-retest variability of resting-state networks in healthy aging and prodromal Alzheimer's disease |
| title_sort | test retest variability of resting state networks in healthy aging and prodromal alzheimer s disease |
| url | http://www.sciencedirect.com/science/article/pii/S2213158218301992 |
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