McKittrick–Wheelock syndrome presenting with presumed paraneoplastic syndrome extra-ocular muscle enlargement masquerading as thyroid eye disease
Paraneoplastic syndromes (PS) are uncommon and are known to mimic other clinical entities, often carrying significant morbidity and mortality. The commonest cause of extra-ocular muscle enlargement (EOME) is thyroid eye disease (TED). Rarely, PS can cause EOME and masquerade as TED. We describe a 52...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2023-06-01
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| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
| Online Access: | https://edm.bioscientifica.com/view/journals/edm/2023/2/EDM22-0386.xml |
| _version_ | 1797795184267755520 |
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| author | Waqar Ahmad Matthew Hartley Shweta Singh Kenzo Motohashi Su Ann Tee Helen Dallal Dariush Kamali Christopher Matthews Shafie Kamaruddin |
| author_facet | Waqar Ahmad Matthew Hartley Shweta Singh Kenzo Motohashi Su Ann Tee Helen Dallal Dariush Kamali Christopher Matthews Shafie Kamaruddin |
| author_sort | Waqar Ahmad |
| collection | DOAJ |
| description | Paraneoplastic syndromes (PS) are uncommon and are known to mimic other clinical entities, often carrying significant morbidity and mortality. The commonest cause of extra-ocular muscle enlargement (EOME) is thyroid eye disease (TED). Rarely, PS can cause EOME and masquerade as TED. We describe a 52-year-old female who presented with diarrhoea, acute kidney injury and electrolyte imbalance. An ophthalmic review identified right upper lid retraction. MRI orbits showed increased thickness of the inferior and medial recti bilaterally, presumed as TED. Whilst investigating her diarrhoea, imaging revealed a large rectosigmoid tumour which required surgical excision. In the context of electrolyte disturbance and acute kidney injury, a diagnosis of McKittrick–Wheelock syndrome (MWS) was made. Following successful surgery, electrolyte imbalance, diarrhoea and eyelid retraction improved. Repeat MRI orbits displayed complete resolution of EOME. To our knowledge, this is the first case of MWS presenting with PS-EOME masquerading as TED. |
| first_indexed | 2024-03-13T03:14:03Z |
| format | Article |
| id | doaj.art-7fc186a4a5c64d728b4fd21ed6606b33 |
| institution | Directory Open Access Journal |
| issn | 2052-0573 |
| language | English |
| last_indexed | 2024-03-13T03:14:03Z |
| publishDate | 2023-06-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism Case Reports |
| spelling | doaj.art-7fc186a4a5c64d728b4fd21ed6606b332023-06-26T06:17:29ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732023-06-01111510.1530/EDM-22-0386McKittrick–Wheelock syndrome presenting with presumed paraneoplastic syndrome extra-ocular muscle enlargement masquerading as thyroid eye diseaseWaqar Ahmad0Matthew Hartley1Shweta Singh2Kenzo Motohashi3Su Ann Tee4Helen Dallal5Dariush Kamali6Christopher Matthews7Shafie Kamaruddin8County Durham and Darlington NHS Foundation Trust, UKCounty Durham and Darlington NHS Foundation Trust, UKCounty Durham and Darlington NHS Foundation Trust, UKNorth Tees and Hartlepool Hospitals NHS Foundation Trust, UKGateshead Health NHS Foundation Trust, UKCounty Durham and Darlington NHS Foundation Trust, UKCounty Durham and Darlington NHS Foundation Trust, UKCounty Durham and Darlington NHS Foundation Trust, UKCounty Durham and Darlington NHS Foundation Trust, UKParaneoplastic syndromes (PS) are uncommon and are known to mimic other clinical entities, often carrying significant morbidity and mortality. The commonest cause of extra-ocular muscle enlargement (EOME) is thyroid eye disease (TED). Rarely, PS can cause EOME and masquerade as TED. We describe a 52-year-old female who presented with diarrhoea, acute kidney injury and electrolyte imbalance. An ophthalmic review identified right upper lid retraction. MRI orbits showed increased thickness of the inferior and medial recti bilaterally, presumed as TED. Whilst investigating her diarrhoea, imaging revealed a large rectosigmoid tumour which required surgical excision. In the context of electrolyte disturbance and acute kidney injury, a diagnosis of McKittrick–Wheelock syndrome (MWS) was made. Following successful surgery, electrolyte imbalance, diarrhoea and eyelid retraction improved. Repeat MRI orbits displayed complete resolution of EOME. To our knowledge, this is the first case of MWS presenting with PS-EOME masquerading as TED.https://edm.bioscientifica.com/view/journals/edm/2023/2/EDM22-0386.xml |
| spellingShingle | Waqar Ahmad Matthew Hartley Shweta Singh Kenzo Motohashi Su Ann Tee Helen Dallal Dariush Kamali Christopher Matthews Shafie Kamaruddin McKittrick–Wheelock syndrome presenting with presumed paraneoplastic syndrome extra-ocular muscle enlargement masquerading as thyroid eye disease Endocrinology, Diabetes & Metabolism Case Reports |
| title | McKittrick–Wheelock syndrome presenting with presumed paraneoplastic syndrome extra-ocular muscle enlargement masquerading as thyroid eye disease |
| title_full | McKittrick–Wheelock syndrome presenting with presumed paraneoplastic syndrome extra-ocular muscle enlargement masquerading as thyroid eye disease |
| title_fullStr | McKittrick–Wheelock syndrome presenting with presumed paraneoplastic syndrome extra-ocular muscle enlargement masquerading as thyroid eye disease |
| title_full_unstemmed | McKittrick–Wheelock syndrome presenting with presumed paraneoplastic syndrome extra-ocular muscle enlargement masquerading as thyroid eye disease |
| title_short | McKittrick–Wheelock syndrome presenting with presumed paraneoplastic syndrome extra-ocular muscle enlargement masquerading as thyroid eye disease |
| title_sort | mckittrick wheelock syndrome presenting with presumed paraneoplastic syndrome extra ocular muscle enlargement masquerading as thyroid eye disease |
| url | https://edm.bioscientifica.com/view/journals/edm/2023/2/EDM22-0386.xml |
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