Decoding microbial genomes to understand their functional roles in human complex diseases
Abstract Complex diseases such as cardiovascular disease (CVD), obesity, inflammatory bowel disease (IBD), kidney disease, type 2 diabetes (T2D), and cancer have become a major burden to public health and affect more than 20% of the population worldwide. The etiology of complex diseases is not yet c...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-06-01
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| Series: | iMeta |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/imt2.14 |
| _version_ | 1797986389834334208 |
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| author | Yifeng Wang Quanbin Dong Shixian Hu Huayiyang Zou Tingting Wu Jing Shi Haifeng Zhang Yanhui Sheng Wei Sun Xiangqing Kong Lianmin Chen |
| author_facet | Yifeng Wang Quanbin Dong Shixian Hu Huayiyang Zou Tingting Wu Jing Shi Haifeng Zhang Yanhui Sheng Wei Sun Xiangqing Kong Lianmin Chen |
| author_sort | Yifeng Wang |
| collection | DOAJ |
| description | Abstract Complex diseases such as cardiovascular disease (CVD), obesity, inflammatory bowel disease (IBD), kidney disease, type 2 diabetes (T2D), and cancer have become a major burden to public health and affect more than 20% of the population worldwide. The etiology of complex diseases is not yet clear, but they are traditionally thought to be caused by genetics and environmental factors (e.g., dietary habits), and by their interactions. Besides this, increasing pieces of evidence now highlight that the intestinal microbiota may contribute substantially to the health and disease of the human host via their metabolic molecules. Therefore, decoding the microbial genomes has been an important strategy to shed light on their functional potential. In this review, we summarize the roles of the gut microbiome in complex diseases from its functional perspective. We further introduce artificial tools in decoding microbial genomes to profile their functionalities. Finally, state‐of‐the‐art techniques have been highlighted which may contribute to a mechanistic understanding of the gut microbiome in human complex diseases and promote the development of the gut microbiome‐based personalized medicine. |
| first_indexed | 2024-04-11T07:33:08Z |
| format | Article |
| id | doaj.art-7fc242a92c9942aeb9c4712123036464 |
| institution | Directory Open Access Journal |
| issn | 2770-596X |
| language | English |
| last_indexed | 2024-04-11T07:33:08Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | iMeta |
| spelling | doaj.art-7fc242a92c9942aeb9c47121230364642022-12-22T04:36:50ZengWileyiMeta2770-596X2022-06-0112n/an/a10.1002/imt2.14Decoding microbial genomes to understand their functional roles in human complex diseasesYifeng Wang0Quanbin Dong1Shixian Hu2Huayiyang Zou3Tingting Wu4Jing Shi5Haifeng Zhang6Yanhui Sheng7Wei Sun8Xiangqing Kong9Lianmin Chen10Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing Jiangsu ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing Jiangsu ChinaInstitute of Precision Medicine, The First Affiliated Hospital of Sun Yat‐Sen University Sun Yat‐Sen University Guangzhou Guangdong ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing Jiangsu ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing Jiangsu ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing Jiangsu ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing Jiangsu ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing Jiangsu ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing Jiangsu ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing Jiangsu ChinaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing Jiangsu ChinaAbstract Complex diseases such as cardiovascular disease (CVD), obesity, inflammatory bowel disease (IBD), kidney disease, type 2 diabetes (T2D), and cancer have become a major burden to public health and affect more than 20% of the population worldwide. The etiology of complex diseases is not yet clear, but they are traditionally thought to be caused by genetics and environmental factors (e.g., dietary habits), and by their interactions. Besides this, increasing pieces of evidence now highlight that the intestinal microbiota may contribute substantially to the health and disease of the human host via their metabolic molecules. Therefore, decoding the microbial genomes has been an important strategy to shed light on their functional potential. In this review, we summarize the roles of the gut microbiome in complex diseases from its functional perspective. We further introduce artificial tools in decoding microbial genomes to profile their functionalities. Finally, state‐of‐the‐art techniques have been highlighted which may contribute to a mechanistic understanding of the gut microbiome in human complex diseases and promote the development of the gut microbiome‐based personalized medicine.https://doi.org/10.1002/imt2.14gut microbiomemetabolitescomplex diseasehost–microbe interactions |
| spellingShingle | Yifeng Wang Quanbin Dong Shixian Hu Huayiyang Zou Tingting Wu Jing Shi Haifeng Zhang Yanhui Sheng Wei Sun Xiangqing Kong Lianmin Chen Decoding microbial genomes to understand their functional roles in human complex diseases iMeta gut microbiome metabolites complex disease host–microbe interactions |
| title | Decoding microbial genomes to understand their functional roles in human complex diseases |
| title_full | Decoding microbial genomes to understand their functional roles in human complex diseases |
| title_fullStr | Decoding microbial genomes to understand their functional roles in human complex diseases |
| title_full_unstemmed | Decoding microbial genomes to understand their functional roles in human complex diseases |
| title_short | Decoding microbial genomes to understand their functional roles in human complex diseases |
| title_sort | decoding microbial genomes to understand their functional roles in human complex diseases |
| topic | gut microbiome metabolites complex disease host–microbe interactions |
| url | https://doi.org/10.1002/imt2.14 |
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