Expanding the Scope of the Cleavable <i>N</i>-(Methoxy)oxazolidine Linker for the Synthesis of Oligonucleotide Conjugates

Expanding the Scope of the Cleavable <i>N</i>-(Methoxy)oxazolidine Linker for the Synthesis of Oligonucleotide Conjugates

Oligonucleotides modified by a 2′-deoxy-2′-(<i>N</i>-methoxyamino) ribonucleotide react readily with aldehydes in slightly acidic conditions to yield the corresponding <i>N</i>-(methoxy)oxazolidine-linked oligonucleotide-conjugates. The reaction is reversible and dynamic in s...

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Bibliographic Details
Main Authors: Aapo Aho, Antti Äärelä, Heidi Korhonen, Pasi Virta
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
oligonucleotide conjugates
cleavable linker
<i>N</i>-(methoxy)oxazolidine
Online Access:https://www.mdpi.com/1420-3049/26/2/490

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