Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cellss⃞

Ceramide kinase promotes Ca2+ signaling near IgG-opsonized targets and enhances phagolysosomal fusion in COS-1 cellss⃞

Ceramide-1-phosphate (C1P) is a novel bioactive sphingolipid formed by the phosphorylation of ceramide catalyzed by ceramide kinase (CERK). In this study, we evaluated the mechanism by which increased C1P during phagocytosis enhances phagocytosis and phagolysosome formation in COS-1 cells expressing...

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Bibliographic Details
Main Authors: Vania Hinkovska-Galcheva, Andrea Clark, Susan VanWay, Ji-Biao Huang, Miki Hiraoka, Akira Abe, Michael Borofsky, Robin G. Kunkel, Thomas Shanley, James A. Shayman, Frederick Lanni, Howard R. Petty, Laurence A. Boxer
Format: Article
Language:English
Published: Elsevier 2008-03-01
Series:Journal of Lipid Research
Subjects:
immunoglobulin G
ceramide-1-phosphate
store operated channels
transient potential channel
phagocytosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520424113

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