Control of Ca2+ Influx and Calmodulin Activation by SK-Channels in Dendritic Spines.

Control of Ca2+ Influx and Calmodulin Activation by SK-Channels in Dendritic Spines.

The key trigger for Hebbian synaptic plasticity is influx of Ca2+ into postsynaptic dendritic spines. The magnitude of [Ca2+] increase caused by NMDA-receptor (NMDAR) and voltage-gated Ca2+ -channel (VGCC) activation is thought to determine both the amplitude and direction of synaptic plasticity by...

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Bibliographic Details
Main Authors: Thom Griffith, Krasimira Tsaneva-Atanasova, Jack R Mellor
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-05-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4883788?pdf=render

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