Physiology and ecology combine to determine host and vector importance for Ross River virus
Identifying the key vector and host species that drive the transmission of zoonotic pathogens is notoriously difficult but critical for disease control. We present a nested approach for quantifying the importance of host and vectors that integrates species’ physiological competence with their ecolog...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2021-08-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/67018 |
| _version_ | 1811236754324193280 |
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| author | Morgan P Kain Eloise B Skinner Andrew F van den Hurk Hamish McCallum Erin A Mordecai |
| author_facet | Morgan P Kain Eloise B Skinner Andrew F van den Hurk Hamish McCallum Erin A Mordecai |
| author_sort | Morgan P Kain |
| collection | DOAJ |
| description | Identifying the key vector and host species that drive the transmission of zoonotic pathogens is notoriously difficult but critical for disease control. We present a nested approach for quantifying the importance of host and vectors that integrates species’ physiological competence with their ecological traits. We apply this framework to a medically important arbovirus, Ross River virus (RRV), in Brisbane, Australia. We find that vertebrate hosts with high physiological competence are not the most important for community transmission; interactions between hosts and vectors largely underpin the importance of host species. For vectors, physiological competence is highly important. Our results identify primary and secondary vectors of RRV and suggest two potential transmission cycles in Brisbane: an enzootic cycle involving birds and an urban cycle involving humans. The framework accounts for uncertainty from each fitted statistical model in estimates of species’ contributions to transmission and has has direct application to other zoonotic pathogens. |
| first_indexed | 2024-04-12T12:14:39Z |
| format | Article |
| id | doaj.art-7fc5ca1acb134e43a413d68a633d130a |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T12:14:39Z |
| publishDate | 2021-08-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-7fc5ca1acb134e43a413d68a633d130a2022-12-22T03:33:29ZengeLife Sciences Publications LtdeLife2050-084X2021-08-011010.7554/eLife.67018Physiology and ecology combine to determine host and vector importance for Ross River virusMorgan P Kain0https://orcid.org/0000-0003-0605-7289Eloise B Skinner1https://orcid.org/0000-0002-9032-2710Andrew F van den Hurk2https://orcid.org/0000-0001-6262-831XHamish McCallum3https://orcid.org/0000-0002-3493-0412Erin A Mordecai4https://orcid.org/0000-0002-4402-5547Department of Biology, Stanford University, Stanford, United States; Natural Capital Project, Woods Institute for the Environment, Stanford University, Stanford, United StatesDepartment of Biology, Stanford University, Stanford, United States; Centre for Planetary Health and Food Security, Griffith University, Gold Coast, AustraliaPublic Health Virology, Forensic and Scientific Services, Department of Health, Brisbane, AustraliaCentre for Planetary Health and Food Security, Griffith University, Gold Coast, AustraliaDepartment of Biology, Stanford University, Stanford, United StatesIdentifying the key vector and host species that drive the transmission of zoonotic pathogens is notoriously difficult but critical for disease control. We present a nested approach for quantifying the importance of host and vectors that integrates species’ physiological competence with their ecological traits. We apply this framework to a medically important arbovirus, Ross River virus (RRV), in Brisbane, Australia. We find that vertebrate hosts with high physiological competence are not the most important for community transmission; interactions between hosts and vectors largely underpin the importance of host species. For vectors, physiological competence is highly important. Our results identify primary and secondary vectors of RRV and suggest two potential transmission cycles in Brisbane: an enzootic cycle involving birds and an urban cycle involving humans. The framework accounts for uncertainty from each fitted statistical model in estimates of species’ contributions to transmission and has has direct application to other zoonotic pathogens.https://elifesciences.org/articles/67018host competencevector competencenext generation matrixdisease spilloveremerging arbovirus |
| spellingShingle | Morgan P Kain Eloise B Skinner Andrew F van den Hurk Hamish McCallum Erin A Mordecai Physiology and ecology combine to determine host and vector importance for Ross River virus eLife host competence vector competence next generation matrix disease spillover emerging arbovirus |
| title | Physiology and ecology combine to determine host and vector importance for Ross River virus |
| title_full | Physiology and ecology combine to determine host and vector importance for Ross River virus |
| title_fullStr | Physiology and ecology combine to determine host and vector importance for Ross River virus |
| title_full_unstemmed | Physiology and ecology combine to determine host and vector importance for Ross River virus |
| title_short | Physiology and ecology combine to determine host and vector importance for Ross River virus |
| title_sort | physiology and ecology combine to determine host and vector importance for ross river virus |
| topic | host competence vector competence next generation matrix disease spillover emerging arbovirus |
| url | https://elifesciences.org/articles/67018 |
| work_keys_str_mv | AT morganpkain physiologyandecologycombinetodeterminehostandvectorimportanceforrossrivervirus AT eloisebskinner physiologyandecologycombinetodeterminehostandvectorimportanceforrossrivervirus AT andrewfvandenhurk physiologyandecologycombinetodeterminehostandvectorimportanceforrossrivervirus AT hamishmccallum physiologyandecologycombinetodeterminehostandvectorimportanceforrossrivervirus AT erinamordecai physiologyandecologycombinetodeterminehostandvectorimportanceforrossrivervirus |