A fully automated normothermic machine perfusion system for kidney grafts supporting physiological motivated flow profiles
Research showed that the normothermic machine perfusion of kidneys can enable prolonged storage and improve conditions compared to traditional cold storage. For research in this area, there is a demand for a long-term in vitro perfusion setup. In this work, we present a fully automated normothermic...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2023-09-01
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| Series: | Current Directions in Biomedical Engineering |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cdbme-2023-1081 |
| _version_ | 1827780088677007360 |
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| author | Wiartalla Marc Berg Frederik Kühn Jahn Buglowski Mateusz Bleilevens Christian Kowalewski Stefan Stollenwerk André |
| author_facet | Wiartalla Marc Berg Frederik Kühn Jahn Buglowski Mateusz Bleilevens Christian Kowalewski Stefan Stollenwerk André |
| author_sort | Wiartalla Marc |
| collection | DOAJ |
| description | Research showed that the normothermic machine perfusion of kidneys can enable prolonged storage and improve conditions compared to traditional cold storage. For research in this area, there is a demand for a long-term in vitro perfusion setup. In this work, we present a fully automated normothermic machine perfusion (NMP) system as an experimental research platform. The perfusion system is intended as a tool for researching the effects of different perfusion strategies on the kidney. To enable the automation, the NMP system consists of a blood pressure control, a circulation volume level control and a pH-regulation component. The setup is realized as a medical cyber-physical system consisting of networked embedded microcontroller nodes. |
| first_indexed | 2024-03-11T15:00:51Z |
| format | Article |
| id | doaj.art-7fc7bc6428e34949a78f29e7909fa164 |
| institution | Directory Open Access Journal |
| issn | 2364-5504 |
| language | English |
| last_indexed | 2024-03-11T15:00:51Z |
| publishDate | 2023-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Current Directions in Biomedical Engineering |
| spelling | doaj.art-7fc7bc6428e34949a78f29e7909fa1642023-10-30T07:58:12ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042023-09-019132332610.1515/cdbme-2023-1081A fully automated normothermic machine perfusion system for kidney grafts supporting physiological motivated flow profilesWiartalla Marc0Berg Frederik1Kühn Jahn2Buglowski Mateusz3Bleilevens Christian4Kowalewski Stefan5Stollenwerk André6Informatik 11 - Embedded Software, RWTH Aachen University, Ahornstraße 55, Aachen, GermanyInformatik 11 - Embedded Software, RWTH Aachen University, Aachen, GermanyInformatik 11 - Embedded Software, RWTH Aachen University, Aachen, GermanyInformatik 11 - Embedded Software, RWTH Aachen University, Aachen, GermanyDepartment of Anesthesiology, Medical Faculty RWTH Aachen University Hospital, Aachen, GermanyInformatik 11 - Embedded Software, RWTH Aachen University, Aachen, GermanyInformatik 11 - Embedded Software, RWTH Aachen University, Aachen, GermanyResearch showed that the normothermic machine perfusion of kidneys can enable prolonged storage and improve conditions compared to traditional cold storage. For research in this area, there is a demand for a long-term in vitro perfusion setup. In this work, we present a fully automated normothermic machine perfusion (NMP) system as an experimental research platform. The perfusion system is intended as a tool for researching the effects of different perfusion strategies on the kidney. To enable the automation, the NMP system consists of a blood pressure control, a circulation volume level control and a pH-regulation component. The setup is realized as a medical cyber-physical system consisting of networked embedded microcontroller nodes.https://doi.org/10.1515/cdbme-2023-1081normothermic machine perfusionlong-term in vitro perfusion setupmedical cyber-physical system |
| spellingShingle | Wiartalla Marc Berg Frederik Kühn Jahn Buglowski Mateusz Bleilevens Christian Kowalewski Stefan Stollenwerk André A fully automated normothermic machine perfusion system for kidney grafts supporting physiological motivated flow profiles Current Directions in Biomedical Engineering normothermic machine perfusion long-term in vitro perfusion setup medical cyber-physical system |
| title | A fully automated normothermic machine perfusion system for kidney grafts supporting physiological motivated flow profiles |
| title_full | A fully automated normothermic machine perfusion system for kidney grafts supporting physiological motivated flow profiles |
| title_fullStr | A fully automated normothermic machine perfusion system for kidney grafts supporting physiological motivated flow profiles |
| title_full_unstemmed | A fully automated normothermic machine perfusion system for kidney grafts supporting physiological motivated flow profiles |
| title_short | A fully automated normothermic machine perfusion system for kidney grafts supporting physiological motivated flow profiles |
| title_sort | fully automated normothermic machine perfusion system for kidney grafts supporting physiological motivated flow profiles |
| topic | normothermic machine perfusion long-term in vitro perfusion setup medical cyber-physical system |
| url | https://doi.org/10.1515/cdbme-2023-1081 |
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