National strategy for the integration of pharmacovigilance in the Moroccan TB Control Program
The objective of this work is to demonstrate the interest of integration of pharmacovigilance in Moroccan Tuberculosis Control Program (MTCP). The integration of pharmacovigilance in MTCP was conducted in October 2012with the Global Fund support. We compared the reports notified before and after thi...
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The Pan African Medical Journal
2017-01-01
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https://www.panafrican-med-journal.com/content/article/26/48/pdf/48.pdf
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| author | Driss Soussi Tanani Samira Serragui Sanae Hammi Latifa Ait Moussa Abdelmajid Soulaymani Rachida Soulaymani Yahia Cherrah |
| author_facet | Driss Soussi Tanani Samira Serragui Sanae Hammi Latifa Ait Moussa Abdelmajid Soulaymani Rachida Soulaymani Yahia Cherrah |
| author_sort | Driss Soussi Tanani |
| collection | DOAJ |
| description | The objective of this work is to demonstrate the interest of integration of pharmacovigilance in Moroccan Tuberculosis Control Program (MTCP). The integration of pharmacovigilance in MTCP was conducted in October 2012with the Global Fund support. We compared the reports notified before and after this integration (period 1: January 2010-October2012; period 2: October 2012-December 2013). The detection of signals was based on the Information Component available inVigiMine. We used the SPSS version 10.0 and Med Calc version 7.3 for data analysis. The average number of spontaneous reports increased from 3.6 to 37.4 cases/month (P= 10-3). The average age was 40.7 , 17.5 years; the sex ratio was 0.8. Hepatic reactions (32.7%) predominated during the first period, while skin reactions (24.1%) were in the second period (P = 10-4), and40.9% of cases in the first period were serious against 15.8% in second period (P = 0.003). Nine signals were generated (hepaticenzyme increase, cholestasis, jaundice, arthralgia, acne, lower limb edema, pruritus, skin rashes, and vomiting). The integration of pharmacovigilance in Moroccan Tuberculosis Control Program improved the management of ADRs and detected new signals of antituberculosis drugs. |
| first_indexed | 2024-12-10T17:36:38Z |
| format | Article |
| id | doaj.art-7fc93446baad4d6c8614e10b3a99c412 |
| institution | Directory Open Access Journal |
| issn | 1937-8688 1937-8688 |
| language | English |
| last_indexed | 2024-12-10T17:36:38Z |
| publishDate | 2017-01-01 |
| publisher | The Pan African Medical Journal |
| record_format | Article |
| series | The Pan African Medical Journal |
| spelling | doaj.art-7fc93446baad4d6c8614e10b3a99c4122022-12-22T01:39:31ZengThe Pan African Medical JournalThe Pan African Medical Journal1937-86881937-86882017-01-01264810.11604/pamj.2017.26.48.73947394National strategy for the integration of pharmacovigilance in the Moroccan TB Control ProgramDriss Soussi Tanani0Samira Serragui1Sanae Hammi2Latifa Ait Moussa3Abdelmajid Soulaymani4Rachida Soulaymani5Yahia Cherrah6 1Department of Pharmacology, Faculty of Medicine and Pharmacy, University of Abdelmalek Essaadi Tanger 90100, Morocco Department of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University of Mohamed V Rabat 10170, Morocco Department of Pneumology, Faculty of Medicine and Pharmacy, University of Abdelmalek Essaadi Tanger 90100, Morocco Moroccan Anti Poison and Pharmacovigilance Center, Rabat 10170, Morocco Laboratory of Genetics and Biometry, University Ibn Tofail, Kenitra 14000, Morocco Moroccan Anti Poison and Pharmacovigilance Center, Rabat 10170, Morocco Department of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University of Mohamed V Rabat 10170, Morocco The objective of this work is to demonstrate the interest of integration of pharmacovigilance in Moroccan Tuberculosis Control Program (MTCP). The integration of pharmacovigilance in MTCP was conducted in October 2012with the Global Fund support. We compared the reports notified before and after this integration (period 1: January 2010-October2012; period 2: October 2012-December 2013). The detection of signals was based on the Information Component available inVigiMine. We used the SPSS version 10.0 and Med Calc version 7.3 for data analysis. The average number of spontaneous reports increased from 3.6 to 37.4 cases/month (P= 10-3). The average age was 40.7 , 17.5 years; the sex ratio was 0.8. Hepatic reactions (32.7%) predominated during the first period, while skin reactions (24.1%) were in the second period (P = 10-4), and40.9% of cases in the first period were serious against 15.8% in second period (P = 0.003). Nine signals were generated (hepaticenzyme increase, cholestasis, jaundice, arthralgia, acne, lower limb edema, pruritus, skin rashes, and vomiting). The integration of pharmacovigilance in Moroccan Tuberculosis Control Program improved the management of ADRs and detected new signals of antituberculosis drugs. https://www.panafrican-med-journal.com/content/article/26/48/pdf/48.pdf pharmacovigilanceadverse drug reactionsantituberculosis drugs |
| spellingShingle | Driss Soussi Tanani Samira Serragui Sanae Hammi Latifa Ait Moussa Abdelmajid Soulaymani Rachida Soulaymani Yahia Cherrah National strategy for the integration of pharmacovigilance in the Moroccan TB Control Program The Pan African Medical Journal pharmacovigilance adverse drug reactions antituberculosis drugs |
| title | National strategy for the integration of pharmacovigilance in the Moroccan TB Control Program |
| title_full | National strategy for the integration of pharmacovigilance in the Moroccan TB Control Program |
| title_fullStr | National strategy for the integration of pharmacovigilance in the Moroccan TB Control Program |
| title_full_unstemmed | National strategy for the integration of pharmacovigilance in the Moroccan TB Control Program |
| title_short | National strategy for the integration of pharmacovigilance in the Moroccan TB Control Program |
| title_sort | national strategy for the integration of pharmacovigilance in the moroccan tb control program |
| topic | pharmacovigilance adverse drug reactions antituberculosis drugs |
| url |
https://www.panafrican-med-journal.com/content/article/26/48/pdf/48.pdf
|
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